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Stroke following Bothrops spp. snakebite
- Jacob C. Tony, 4 Eltham Gardens, Maybank, Newcastle-under-Lyme, staffs, UK, ST5 OJR (25 June 2003)
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Jacob C. Tony, Physician Specialist Registrar, Medicine,, 4 Eltham Gardens, Maybank, Newcastle-under-Lyme, staffs, UK, ST5 OJR
Send Correspondence to journal:
tjacob33{at}hotmail.com Jacob C. Tony, et al.
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In explaining the pathogenesis of cerebral infarction following snake bite, Mosquera et al suggest a procoagulant effect of the venom and toxic angiitis of intracranial vessels as the cause for cerebral infarction [1]. Sarafotoxin in snake venom has vascular toxic effects leading to vasospasm particularly in the coronary vessels [2]. Myocardial infarction following snake bite has been reported, and sarafotoxins are implicated in such situations [3]. Sarafotoxin-like peptides in the venom of Bothrops spp. may contribute to cerebral infarction in a similar manner as the pathogenesis of myocardial infarction. References 1. Mosquera A, Idrovo LA, Tafur- A, Dell Brutto OH.Stroke following Bothrops spp.snakebite.Neurology2003;60:1577-1580. 2. Wollberg Z,Bdolah A,Kochva E. Cardiovascular effects of mammalian endothelins and snake venom sarafotoxins.In:Abraham S, Amitai G,eds.Calcium Channel Modulators in Heart and smooth Muscle. Florida:VCH, Weinheim/Deerfield Beach,1990:283-99 3. Tony JC, Bhat R. Acute myocardial infarction following snake bite.Tropical Doctor. 1995;25:137 |
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