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Correspondence: When an article is eligible for submission of Correspondence, a link to the response form is available within the full-text article. You must be a current subscriber who has activated the online portion of your subscription in order to send a Correspondence. Any reader can read published Correspondence.
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Correspondence:Correspondence published:
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Autopsy-confirmation of hippocampal atrophy in AD
- A. David Smith (27 June 2002)
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A. David Smith, Professor of Pharmacology University of Oxford
Send Correspondence to journal:
david.smith{at}pharm.ox.ac.uk A. David Smith
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The authors of this state that “Previous studies examining the association of hippocampal atrophy with AD have lacked autopsy confirmation.” [1]. However, they seem to be unaware of studies published ten years ago in which atrophy of the medial temporal lobe assessed in life by CT scans was shown to be a sensitive and specific marker for pathologically-confirmed AD. [2]. Since then, several authors have confirmed this finding and have correlated hippocampal atrophy with the progression of AD and with autopsy studies on neuronal loss and on neurofibrillary tangle density. [3] References [1] Gosche KM, Mortimer JA, Smith CD, Markesbery WR, Snowdon DA. Hippocampal volume as an index of Alzheimer neuropathology: Findings from the Nun Study Neurology 2002; 58: 1476-1482. [2] Jobst KA, Smith AD, et al. Detection in life of confirmed Alzheimer's disease using a simple measurement of medial temporal lobe atrophy by computed tomography. Lancet 1992, 340: 1179-1183. [3] Smith AD. Imaging the progression of Alzheimer pathology through the brain. Proc Natl Acad Sci U S A 2002, 99: 4135-4137. |
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