Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
Published online before print January 30, 2008, doi:10.1212/01.wnl.0000306308.08229.a3)
This Article
Right arrow Full Text (Rapid PDF)
Right arrow CME: Take the course for this article:
 Volume 70, Number 17, April 22, 2008
Right arrow All Versions of this Article:
01.wnl.0000306308.08229.a3v1
70/17/1518    most recent
Right arrow Correspondence:
Submit a response
Right arrow Correspondence:
View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zaidat, O. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zaidat, O. O.
Received June 5, 2007
Accepted November 5, 2007

The NIH registry on use of the Wingspan stent for symptomatic70–99% intracranial arterial stenosis

O. O. Zaidat MD, MS*, R. Klucznik MD, M. J. Alexander MD, FACS, J. Chaloupka MD, H. Lutsep MD, S. Barnwell MD, M. Mawad MD, B. Lane BSN, RN, M. J. Lynn MS, M. Chimowitz MD, For the NIH Multi-center Wingspan Intracranial Stent Registry Study Group

From the Medical College of Wisconsin/Froedtert Hospital (O.O.Z.), Milwaukee; Methodist Hospital (R.K.), Houston, TX; Duke University (M.J.A.), Durham, NC; University of Iowa (J.C.), Iowa City; Oregon Health and Science University (H.L., S.B.), Portland; Baylor College of Medicine (M.M.), Houston, TX; and Emory University (B.L., M.J.L., M.C.), Atlanta, GA.


* To whom correspondence should be addressed. E-mail: szaidat{at}mcw.edu.

Background: The Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) trial showed that patients with symptomatic 70% to 99% intracranial arterial stenosis are at particularly high risk of ipsilateral stroke on medical therapy: 18% at 1 year (95% CI = 3% to 24%). The Wingspan intracranial stent is another therapeutic option but there are limited data on the technical success of stenting and outcome of patients with 70% to 99% stenosis treated with a Wingspan stent.

Methods: Sixteen medical centers enrolled consecutive patients treated with a Wingspan stent in this registry between November 2005 and October 2006. Data on stenting indication, severity of stenosis, technical success (stent placement across the target lesion with <50% residual stenosis), follow-up angiography, and outcome were collected.

Results: A total of 129 patients with symptomatic 70% to 99% intracranial stenosis were enrolled. The technical success rate was 96.7%. The mean pre and post-stent stenoses were 82% and 20%. The frequency of any stroke, intracerebral hemorrhage, or death within 30 days or ipsilateral stroke beyond 30 days was 14.0% at 6 months (95% CI = 8.7% to 22.1%). The frequency of ≥50% restenosis on follow-up angiography was 13/52 (25%).

Conclusion: The use of a Wingspan stent in patients with severe intracranial stenosis is relatively safe with high rate of technical success with moderately high rate of restenosis. Comparison of the event rates in high-risk patients in Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) vs this registry do not rule out either that stenting could be associated with a substantial relative risk reduction (e.g., 50%) or has no advantage compared with medical therapy. A randomized trial comparing stenting with medical therapy is needed.




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
M. Mazighi, J.P. S. Maurice, D. Bresson, Z. Szatmary, and E. Houdart
Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis
AJNR Am. J. Neuroradiol., March 1, 2010; 31(3): 496 - 497.
[Abstract] [Full Text] [PDF]

Home page
 Journal of NeuroInterventional SurgeryHome page
W-J Jiang, B Du, S F K Hon, M Jin, X-T Xu, N Ma, F Gao, and K-H Dong
Do patients with basilar or vertebral artery stenosis have a higher stroke incidence poststenting?
JNIS, March 1, 2010; 2(1): 50 - 54.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
D. C. Suh and E. H. Kim
The Therapeutic Time Window Related to the Presenting Symptom Pattern, That Is, Stable Versus Unstable Patients, Can Affect the Adverse Event Rate of Intracranial Stenting
Stroke, October 1, 2009; 40(10): e588 - e589.
[Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E.F. Hauck, J. Mocco, K.V. Snyder, and E.I. Levy
Temporary Endovascular Bypass: A Novel Treatment for Acute Stroke
AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1532 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
E. A. Samaniego, S. Hetzel, S. Thirunarayanan, B. Aagaard-Kienitz, A. S. Turk, and R. Levine
Outcome of Symptomatic Intracranial Atherosclerotic Disease
Stroke, September 1, 2009; 40(9): 2983 - 2987.
[Abstract] [Full Text] [PDF]

Home page
 Journal of NeuroInterventional SurgeryHome page
T J Wolfe, B F Fitzsimmons, S I Hussain, J R Lynch, and O O Zaidat
Long term clinical and angiographic outcomes with the Wingspan stent for treatment of symptomatic 50-99% intracranial atherosclerosis: single center experience in 51 cases
JNIS, July 3, 2009; (2009) jnis.2009.000331v1.
[Abstract] [Full Text] [PDF]

Home page
 Journal of NeuroInterventional SurgeryHome page
D Fiorella, T N Turan, C P Derdeyn, and M I Chimowitz
Current status of the management of symptomatic intracranial atherosclerotic disease: the rationale for a randomized trial of medical therapy and intracranial stenting
JNIS, July 3, 2009; (2009) jnis.2009.000125v1.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
F. Nahab, M. J. Lynn, S. E. Kasner, M. J. Alexander, R. Klucznik, O. O. Zaidat, J. Chaloupka, H. Lutsep, S. Barnwell, M. Mawad, et al.
Risk factors associated with major cerebrovascular complications after intracranial stenting
Neurology, June 9, 2009; 72(23): 2014 - 2019.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
T. N. Turan, C. P. Derdeyn, D. Fiorella, and M. I. Chimowitz
Treatment of Atherosclerotic Intracranial Arterial Stenosis
Stroke, June 1, 2009; 40(6): 2257 - 2261.
[Full Text] [PDF]

Home page
 StrokeHome page
T. W. Leung, S. C.H. Yu, W. W.M. Lam, A. Y.Y. Chan, A. Y.L. Lau, and L. K.S. Wong
Would Self-Expanding Stent Occlude Middle Cerebral Artery Perforators?
Stroke, May 1, 2009; 40(5): 1910 - 1912.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
K. Groschel, S. Schnaudigel, S. M. Pilgram, K. Wasser, and A. Kastrup
A Systematic Review on Outcome After Stenting for Intracranial Atherosclerosis
Stroke, May 1, 2009; 40(5): e340 - e347.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. M. Meyers, H. C. Schumacher, R. T. Higashida, S. L. Barnwell, M. A. Creager, R. Gupta, C. G. McDougall, D. K. Pandey, D. Sacks, and L. R. Wechsler
Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures: A Scientific Statement From the American Heart Association Council on Cardiovascular Radiology and Intervention, Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Interdisciplinary Council on Peripheral Vascular Disease, and Interdisciplinary Council on Quality of Care and Outcomes Research
Circulation, April 28, 2009; 119(16): 2235 - 2249.
[Full Text] [PDF]

Home page
 NeurologyHome page
T. W. Leung, S. C.H. Yu, W. W.M. Lam, L. K.S. Wong, O. O. Zaidat, and M. Chimowitz
THE NIH REGISTRY ON USE OF THE WINGSPAN STENT FOR SYMPTOMATIC 70-99% INTRACRANIAL ARTERIAL STENOSIS
Neurology, September 30, 2008; 71(14): 1124 - 1125.
[Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C.P. Derdeyn and M.I. Chimowitz
Re: Turk et al and the "How Do We Spin Wingspan?" Commentary
AJNR Am. J. Neuroradiol., September 1, 2008; 29(8): e69 - e69.
[Full Text] [PDF]

Home page
 NeurologyHome page
E. C. Haley Jr
Registries: They're not just for weddings anymore
Neurology, April 22, 2008; 70(17): 1508 - 1509.
[Full Text] [PDF]

Correspondence:

Read all Correspondence

The NIH registry on use of the Wingspan stent for symptomatic 70-99% intracranial arterial stenosis
Thomas W. Leung, et al.
Neurology Online, 27 Mar 2008 [Full text]
Reply from the authors
Osama O Zaidat, et al.
Neurology Online, 27 Mar 2008 [Full text]