Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Published online before print March 22, 2006, doi:10.1212/01.wnl.0000215852.35329.34)
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
01.wnl.0000215852.35329.34v1
66/12/1917    most recent
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schürks, M.
Right arrow Articles by Rosskopf, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schürks, M.
Right arrow Articles by Rosskopf, D.
Received August 1, 2005
Accepted January 18, 2006

Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene

M. Schürks MD*, T. Kurth MD, ScD, I. Geissler , G. Tessmann , H.-C. Diener MD, and D. Rosskopf MD

From the Department of Neurology (M.S., H.-C.D.), University of Duisburg-Essen, Germany; Divisions of Preventive Medicine and Aging (T.K.), Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, and Department of Epidemiology, Harvard School of Public Health, Boston, MA; and Institute of Pharmacology (I.G., G.T., D.R.), Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University Hospital, Ernst-Moritz Arndt University, Greifswald, Germany.


* To whom correspondence should be addressed. E-mail: schuerks{at}hotmail.com.

Abstract-- The G1246A polymorphism in the gene of the hypocretin receptor 2 (HCRTR2) has been linked to the risk for cluster headache (CH). The authors examined this association in a large sample of 226 patients with CH and 266 controls from Germany. The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007).






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by AAN Enterprises, Inc.