Teaching NeuroImages: "Penguin" or "hummingbird" sign and midbrain atrophy in progressive supranuclear palsy
Jerome J. Graber, MD, MPH and
Robert Staudinger, MD, FAAN
From the Department of Neurology, New York University School of Medicine; and Department of Neurology, New York Harbor Veteran's Affairs Medical Center, New York.
Address correspondence and reprint requests to Dr. Jerome J. Graber, Department of Neurology, New York University School of Medicine, NBV7W11, 462 First Avenue, New York, NY 10016 Jerome.Graber{at}nyumc.org
An 82-year-old man presented to us with a 2-year history ofprogressive difficulty walking. On examination, he had bradykinesia,bradyphrenia, axial rigidity without appendicular rigidity,cogwheeling, or tremor, and restriction of upward and downwardgaze. Imaging revealed prominent midbrain atrophy without pontineatrophy, referred to as the "penguin" or "hummingbird" sign(figure), which may be helpful in distinguishing progressivesupranuclear palsy from multisystem atrophy, Parkinson disease,and healthy controls.1,2
Figure Midsagittal MRI of the brain demonstrates prominent midbrain atrophy without pontine atrophy (divided by white line), forming the silhouette of the "penguin" or "hummingbird" sign
Oba H, Yagashita A, Terada H, et al. New and reliable MRI diagnosis for progressive supranuclear palsy. Neurology 2005;64:2050–2055.[Abstract/Free Full Text]
Kato N, Arai K, Hattori T. Study of the rostral midbrain atrophy in progressive supranuclear palsy. J Neurol Sci 2003;210:57–60.[Medline]