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From the Department of Neurology (Dr. Petersen), Mayo Clinic, Rochester, MN; Lutheran Medical Office (Dr. Stevens), Fort Wayne, IN; Department of Psychiatry, University of Pittsburgh School of Medicine and Department of Epidemiology, University of Pittsburgh Graduate School of Public Health (Dr. Ganguli), Pittsburgh, PA; Department of Internal Medicine (Dr. Tangalos), Mayo Clinic, Rochester, MN; Departments of Neurology and Psychiatry & Biobehavioral Science (Dr. Cummings), University of California at Los Angeles; Departments of Neurology and Psychiatry (Dr. DeKosky), University of Pittsburgh, PA.
Address correspondence and reprint requests to the Quality Standards Subcommittee, American Academy of Neurology, 1080 Montreal Ave., St. Paul, MN 55116.
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Article Abstract |
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 Top. Article Abstract IntroductionClinical question statement.Process.Recommendations for future...AppendixReferences |
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BACKGROUND: Epidemiologic studies of aging and dementia have demonstrated that the use of research criteria for the classification of dementia has yielded three groups of subjects: those who are demented, those who are not demented, and a third group of individuals who cannot be classified as normal or demented but who are cognitively (usually memory) impaired.
METHODS: The authors conducted computerized literature searches and generated a set of abstracts based on text and index words selected to reflect the key issues to be addressed. Articles were abstracted to determine whether there were sufficient data to recommend the screening of asymptomatic individuals. Other research studies were evaluated to determine whether there was value in identifying individuals who were memory-impaired beyond what one would expect for age but who were not demented. Finally, screening instruments and evaluation techniques for the identification of cognitive impairment were reviewed.
RESULTS: There were insufficient data to make any recommendations regarding cognitive screening of asymptomatic individuals. Persons with memory impairment who were not demented were characterized in the literature as having mild cognitive impairment. These subjects were at increased risk for developing dementia or AD when compared with similarly aged individuals in the general population.
RECOMMENDATIONS: There were sufficient data to recommend the evaluation and clinical monitoring of persons with mild cognitive impairment due to their increased risk for developing dementia (Guideline). Screening instruments, e.g., Mini-Mental State Examination, were found to be useful to the clinician for assessing the degree of cognitive impairment (Guideline), as were neuropsychologic batteries (Guideline), brief focused cognitive instruments (Option), and certain structured informant interviews (Option). Increasing attention is being paid to persons with mild cognitive impairment for whom treatment options are being evaluated that may alter the rate of progression to dementia.
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Introduction |
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Top.Article AbstractIntroductionClinical question statement.Process.Recommendations for future...AppendixReferences |
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Initially, the members of the detection work group phrased the following clinical question: Does screening of subjects with a specific instrument in a specific setting accurately lead to the diagnosis of dementia? After an extensive literature review, the work group concluded that there were insufficient data in the literature to allow an evidence-based approach to the question of the clinical utility of screening asymptomatic individuals for dementia. Epidemiologic studies of aging and dementia have demonstrated that the use of research criteria for the classification of dementia identifies three groups of subjects: those who are demented, those who are not demented, and individuals who cannot be classified because they have a cognitive (memory) impairment but do not meet criteria for dementia. The work group then turned its attention to an evaluation of this group of subjects.
In the recent literature, attention has been paid to the transitional stage of cognitive impairment between normal aging and early AD, so-called mild cognitive impairment.2 Mild cognitive impairment refers to the clinical state of individuals who are memory impaired but are otherwise functioning well and do not meet clinical criteria for dementia ( table 1). Several multicenter treatment trials are under way to determine whether various therapeutic measures can alter the rate at which these subjects progress to AD. Collectively, these studies emphasize the need for the clinician to detect the earliest signs of cognitive impairment. This practice parameter was modified to determine whether screening at-risk subjects (by virtue of memory impairment) with a specific instrument in a specific setting leads to the diagnosis of dementia.
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Clinical question statement. |
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Top.Article AbstractIntroductionClinical question statement.Process.Recommendations for future...AppendixReferences |
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Process. |
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Top.Article AbstractIntroductionClinical question statement.Process.Recommendations for future...AppendixReferences |
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Literature review process. Search terms. Key and index words used were as follows: dementia, presenile dementia, senile dementia, vascular dementia, AD, early detection, early diagnosis, early stages, early symptoms, health screening, psychologic screening inventory, geriatric assessment, longitudinal studies, retrospective studies, mild cognitive impairment, Mini-Mental State Examination, cognitive impairment, cognitive assessment, and memory tests.
Data bases. MEDLINE, EMBASE, Current Contents, Psychological Abstracts, Psych Info, Cochrane Database, and CINAHL Database were searched.
Inclusion/exclusion criteria and process. For the searches we sought studies in all languages; however, other types of studies were limited to English only. Studies were restricted to human subjects. Longitudinal prospective studies that evaluated mildly impaired subjects and followed them to detect cognitive impairment from 1991 to early 2000 were reviewed. We also examined reviews and their bibliographies published from 1994 to November 1999 to identify additional articles. In addition, we evaluated studies of clinical testing instruments that could be used to identify subjects with cognitive impairment.
Number and disposition of articles. We identified 1,933 abstracts, which yielded 120 articles. Application of appropriate inclusion/exclusion criteria yielded 74 articles that provided the evidence for this parameter.
Data extraction items. Articles were reviewed by at least two individuals and selected items were coded onto a data extraction form that had the following information: type of article, focus of article (e.g., diagnosis of dementia, early dementia), number of subjects, sex, subject selection method, method of patient characterization, screening instruments used, final diagnostic classification, gold standard for final diagnostic classification, quality of diagnostic methods, formal diagnostic criteria used, diagnostic criteria for AD (if applicable), age of population studied (if study dealt with test or instrument), name and value, sensitivity, specificity, positive predictive value, negative predictive value, and final classification of evidence.
Classification of evidence. Each article was assigned to a class of evidence based on a priori definitions ( table 2). The class of evidence determined whether or not study results were ultimately translated into Standards, Guidelines, or Options ( table 3).
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Analysis of evidence. Does the presence of mild cognitive impairment predict the development of dementia? The work group assessed longitudinal studies of persons with mild cognitive impairment to determine whether classification of such persons leads to an increased risk of developing AD relative to the general age-matched population. Overall ("crude") estimates are less than adequate for comparison among studies because study cohorts may vary in their age structures. Even when using age-specific or age-adjusted incidence rates, varying diagnostic/inclusion criteria affect comparability of studies. For example, some studies include persons with incipient dementia, others include mild dementia, and still others only included individuals with moderate to severe dementia.5,6 As an example of the effect of such difference, two studies of largely white cohorts in the northeastern United States generated widely disparate incidence rates. The age-specific annual incidence rates for AD in the group aged 60 to 65 was 0.6% per year in the East Boston study.7 This study included mild cases and did not require functional impairment for the definition of dementia. In contrast, in the Framingham study only individuals with moderate to severe dementia were included and the incidence was 0.07% per year,8 one-tenth of the rate reported from East Boston. However, in both the Framingham and the East Boston studies the incidence rates for the group aged 85+ were 14 times higher than in the 65 to 69 age group.7,8
Table 4 gives estimated, annual age-specific incidence rates for all dementias and for AD averaged in a meta-analysis of 12 studies by Gao et al.9 The average incidence rate for AD across studies for ages 70 to 74 years is 0.51%, increasing to 3.9% at ages 85 to 89.
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In another Class II Canadian study from a similar setting in Toronto, 107 subjects with a memory impairment without dementia were followed for 2 years.14,15 Subjects were referred to the study by family physicians, and the mean age of the subjects was 74 years. During the 2-year follow-up, 29 (approximately 28%) developed AD for an approximate annual conversion rate of 14%.
A Class II U.S. study exploring the natural history of subjects from a memory disorders clinic at Columbia University evaluated 127 consecutive subjects with "questionable dementia." However, these subjects did not meet criteria for dementia.16 This group represented subjects seen in a referral setting with a mean age of 66 years. Approximately 40% of the subjects were not followed for various reasons. During the course of 2.7 years, 41.3% of the subjects who were followed became demented for an annual conversion rate of approximately 15%.
In a recent U.S. Class II study from Massachusetts General Hospital, persons were recruited from the community through media advertisements.17 A total of 123 persons with a Clinical Dementia Rating (CDR) of 0.5 (questionable dementia) were followed for 3 years. During this time frame, 23 individuals converted to probable AD for an annual rate of approximately 6%.
In a U.S. Class III study from a large health maintenance organization in Seattle, a group of memory impaired subjects were followed.18 Of 811 subjects with a mean age of 74 years who had been recruited through a registry for cognitive complaints, 21 subjects with a severe isolated memory loss were followed for a mean of 48 months. During this time period, 48% developed dementia for an annual conversion rate of approximately 12% per year.
Investigators at New York University, in a Class III study using the Global Deterioration Scale as a measure to assess impairment, followed individuals with a Global Deterioration Scale rating of 3, which represented mild cognitive impairment for these investigators.19 They found that 16 of 32 of these individuals had progressed to a diagnosis of AD over 2.2 years (25% per year)19 and concluded that mild cognitive impairment was a risk factor for subsequent development of dementia.
Conclusions.
Taken together, these studies indicate that individuals characterized as being cognitively impaired but not meeting clinical criteria for dementia or AD (mild cognitive impairment) have a high risk of progressing to dementia or AD. If the figures for incident AD from the general population are used from table 4, one can see that the rates range from 0.2% in the 65 to 69 age range to 3.9% in the 85 to 89 year range. The studies of mild cognitive impairment cited above indicate that the rate of progression to dementia or AD is between 6 and 25% per year.
Practice recommendation.
Patients with mild cognitive impairment should be recognized and monitored for cognitive and functional decline due to their increased risk for subsequent dementia. (Guideline).
Does screening at-risk subjects with a specific instrument in a specific setting accurately lead to the diagnosis of dementia? Because it is apparent that clinicians should be able to recognize persons in their practices with intermediate stages of cognitive impairment, it is helpful to survey which clinical instruments might be useful. Most of the studies on screening instruments compared dementia and control subjects rather than mild cognitive impairment subjects. The literature on which these recommendations are made is summarized in table 6, according to the classification of instruments. A number of studies evaluated large groups of persons to determine whether screening instruments are useful for recognizing dementia at its earliest presentation. These studies provide useful information on the utility of screening instruments in the community or office practice setting. Most of these studies used the procedure of a screening technique and verified its utility with an independent standard for dementia. A summary of the sensitivities, specificities, and positive and negative predictive values for these instruments is outlined in table 6.
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0.5.21 The CDR is a 5-point scale of severity with a CDR 0 representing normal subjects, CDR 0.5 questionable dementia, and CDR 1, 2, and 3 pertaining to mild, moderate, and severe dementia, respectively. In another study, the MMSE was also evaluated in a registry setting in which 150 consecutive patients with cognitive complaints were administered the examination, and the results were compared with a 1-year follow-up diagnosis.22 These data indicated the standard cutoff score of <24 on the MMSE was insensitive (63%), whereas the specificity was good (96%). There were two U.S. Class II studies that concerned screening general populations with the MMSE. In a large study of the MMSE from the Mayo Clinic, 3513 elderly subjects were administered the MMSE and followed longitudinally.23 The investigators concluded that a decline of 4 or more points in the MMSE over 1 to 4 years indicated a significant cognitive change. When the cutoff scores were adjusted for age and educational levels, the sensitivity improved (82%) while maintaining excellent specificity (99%). When administered to a population with a high prevalence of dementia (20%), the positive predictive value (PPV) was 91% with a negative predictive value (NPV) of 96%. When used in a population with a lower base rate of dementia (5%), the PPV fell to 68% with an NPV of 99%. The MMSE, originally designed as a bedside screening tool for the clinician, therefore appears to have limitations as a screening tool in general population assessments; however, it appeared to be quite useful in examining patients at increased risk for dementia (e.g., Mild Cognitive Impairment), particularly when age and education adjustments were implemented.
In another U.S. population-based study of patients over the age of 65 in North Manhattan, the MMSE was found to have low specificity (44%) when the cutoff point was adjusted to ensure a sensitivity of 90%.24 This study demonstrated the limitations of using the MMSE in isolation when discriminating between demented and nondemented patients in a general population.
In a Class III study from Greece as a part of the World Health Organization Program for Research on Aging and Age-Associated Dementias, the MMSE was compared with the Diagnostic and Statistical Manual (DSM) IV criteria for dementia and the National Institute of Neurologic, Communicative Disorders and Stroke–AD and Related Disorders Association criteria for AD.25 In a sample of 277 subjects with widely varying education from the general population, the MMSE had low specificity (57%) with high sensitivity (100%).
Performance on the Kokmen Short Test of Mental Status was assessed in a sample of 288 consecutive subjects suspected of cognitive impairment referred to a memory clinic.26 The possibility of dementia was considered when an MMSE score was <24 or when a family member or physician suspected a memory impairment. Sensitivity of 86% and specificity of 88% were achieved for detecting dementia as defined by DSM III-R criteria.
In another U.S. Class I study, investigators at Albert Einstein College of Medicine used the Memory Impairment Screen for dementia.27 This screen consisted of a four-item delayed and cued recall test. The investigators studied a sample of 483 elderly individuals, 50 with an independent diagnosis of dementia using the DSM III-R criteria. The memory screening tool demonstrated good sensitivity (87%), specificity (96%), and PPV (85%) when the prevalence of disease was 20%, with a low PPV (54%) when the base rate of disease was 5%.
In another U.S. Class III study a 7-minute screening instrument comprising enhanced cued recall, category fluency, Benton Temporal Orientation Test, and Clock Drawing Test (CDT) was administered to 60 consecutive patients with AD sent to a memory disorders clinic as well as 60 age-matched controls recruited from newspaper ads and by an HMO.28 The sensitivity of this examination was 92% with a specificity of 96%.
Conclusion.
General cognitive screening instruments, which include the MMSE, Kokmen Short Test of Mental Status, 7-Minute Screen, and Memory Impairment Screen, are useful for the detection of dementia when used in patient populations with an elevated prevalence of cognitive impairment either due to age or presence of memory dysfunction.
Practice recommendation.
General cognitive screening instruments (e.g., MMSE) should be considered for the detection of dementia in individuals with suspected cognitive impairment (Guideline).
Brief focused screening instruments.
A tool which has experienced popularity in assessing patients for cognitive impairment is the CDT. Scores are based on the patient’s ability to properly draw the face of a clock by appropriate placement of the numbers and the hands of the clock to a designated time. In the Class II Rancho Bernardo population-based study, 199 patients over the age of 65 were designated as having possible cognitive impairment after undergoing an initial screen.29 They were administered the CDT as were 203 age-matched normal elderly (screen negative) from the same population base. The cutoff scores were determined (using ROC curves) and resulted in sensitivity of 83% and specificity of 72% for the global scores.
In another Class II study, 106 elderly Chinese patients were administered the CDT as well as the tasks of reading the time from a set clock and setting a clock to a designated time.30 When using the designated cutoff points and determining the presence of dementia using the DSM III-R criteria, the CDT demonstrated a moderate sensitivity of 83% and specificity of 79%.
The Time and Change Test, which is an instrument assessing the subject’s ability to tell time and make change, was evaluated in a Class I31 and a Class II32 study. In the Class I study, 100 consecutive patients 70 years of age or older were assessed using this task, and the results were compared with a standard diagnosis based on the Blessed Dementia Rating Scale (BDRS) and the MMSE. The sensitivity in this sample was 94% with a specificity of 46%. These results are limited by use of the BDRS and the MMSE as reference standards for dementia. The authors argue that these instruments have the potential to reduce unrecognized cases of dementia but should not be used in isolation when making the determination of a dementing illness. The Class II study was performed on 776 consecutive inpatients greater than 65 years of age. The instrument demonstrated a moderate specificity (71%) and sensitivity (86%) with a poor PPV (34%) and excellent NPV (97%) when the base rate of disease was 14%.
Conclusion.
Recently attempts have been made to develop useful screening tools that can be administered in a brief time frame. Caution must be exercised because of the limited scope of these tools.
Practice recommendation.
Brief cognitive assessment instruments that focus on limited aspects of cognitive function (i.e., CDT, Time and Change Test) may be considered when screening patients for dementia (Option).
Neuropsychologic batteries.
The utility of neuropsychologic batteries in evaluating patients with possible dementia has been addressed in several Class II studies. The Rancho Bernardo population was examined using tests of verbal and nonverbal memory, mental flexibility, and confrontational naming.33 A logistic model was derived and correctly classified 82% of the subjects with AD and 98% of the normal elderly subjects. When a cross-validation study was performed on an independent sample of 46 subjects (27 normal controls and 19 patients with AD) from a clinic, the sensitivity improved to 89% with the specificity remaining high at 100%. This suggests that psychometric discrimination of AD may be less accurate in a community-dwelling population than in clinic-based samples.
In the North Manhattan Aging Project, 795 patients over the age of 65 were administered a battery of tests and a "culture-fair" neuropsychologic examination.24 When the sensitivity was set to 90% (by using ROC curves) the tests all demonstrated rather poor specificity for detecting dementia (results ranging from 44 to 62%).
Another Class II U.S. study was conducted on 87 patients referred to the University of Massachusetts Memory Clinic who were found to have verbal IQ >110.34 These examinations identified 80% of the demented and 96% of the nondemented subjects correctly. Recall of prose passages was found to be one of the best discriminators of mild dementia versus normal cognition in this elderly sample.
In a Class III study from Italy, a neuropsychologic battery examining activities of daily living, affect, verbal and spatial memory, orientation, calculation, language, writing and reading comprehension, and visuomotor function was tested in 143 subjects with AD and 146 hospitalized age- and education-matched controls.35 These tests, when analyzed using a logistic model, demonstrated a sensitivity of 87% with a specificity of 90% when detecting demented versus nondemented subjects.
Several Class III studies examined various instruments used in the detection of dementia. An object memory test was used on both English- and Spanish-speaking patients recruited from a memory clinic.36 When a cutoff score of 29 points was implemented the test had a specificity of 98% and a sensitivity of 96%. The applicability of these findings to the general elderly population is uncertain.
The Mattis Dementia Rating Scale was assessed in a Class II study in 254 patients with AD and 105 elderly controls.37 This scale tests the areas of attention, initiation/perseveration, construction, memory, and conceptualization. When a cutoff score of 129/144 points was used the sensitivity was 98% and the specificity was 97%. When the rating scale was applied to a community-based sample the test correctly identified 91% of the patients with AD and 93% of the normal elderly subjects.
Conclusion.
Neuropsychologic batteries are useful instruments in identifying patients with dementia, particularly when administered to an increased-risk (by virtue of memory impairment) population. Those neuropsychologic instruments that emphasize memory function are most useful.
Practice recommendation.
Neuropsychologic batteries should be considered useful in identifying patients with dementia, particularly when administered to a population at increased risk of cognitive impairment (Guideline).
Informant-based instruments.
There are a variety of other screening instruments that have been evaluated for their usefulness in identifying patients with dementia. Some of these emphasize history from an informant. In a Class I study, an informant-based technique, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), was used in an illiterate Chinese population consisting of 399 community residents and 61 patients with dementia.38 Performance on the informant-based instrument was compared with an independent diagnosis of dementia by physicians using the DSM III-R criteria. The IQCODE performed well with a sensitivity of 89% and a specificity of 88%. Its performance was better than a derived MMSE score in a population with a large variation in educational background. The authors caution that the examination assumes that the informants are objective and honest with their ratings, and variations from this will significantly alter the results.
The BDRS, a 22-question informant-based instrument, was assessed in 53 demented and 53 age-matched controls in a Class II study.39 The patients were obtained from social centers, retirement homes, and outpatient clinics in Hong Kong. The instrument demonstrated a specificity of 98% and a sensitivity of 91%; however interrater reliability for the individual items on the instrument was poor.
The CDR scale is a 6-category, informant-based examination dealing with orientation, judgment, memory, community affairs, personal care, and home and hobbies.40 In a study of a random sample of 656 Helsinki residents older than 75 years, 174 were found to have a CDR score >0.5.41 These patients were examined by a neurologist using the DSM III-R criteria for defining dementia. When a cutoff score of CDR 1 was used, this instrument demonstrated a specificity of 94% with a sensitivity of 92%.
Conclusion.
Interview-based techniques (i.e., BDRS, CDR, IQCODE) may be useful in identifying patients with dementia, particularly when administered to patients who are at increased risk of developing dementia by virtue of age or memory impairment. These instruments emphasize the importance of obtaining information concerning the cognitive and functional status of persons from an informed source.
Practice recommendation.
Interview-based techniques may be considered in identifying patients with dementia, particularly in a population at increased risk for cognitive impairment (Option).
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Recommendations for future research. |
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Top.Article AbstractIntroductionClinical question statement.Process.Recommendations for future...AppendixReferences |
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Additional studies are needed to allow the clinician to differentiate among the screening instruments assessed in the various studies described above. In particular, there are few studies that address the direct comparison of instruments, e.g., the MMSE versus CDT. These issues become relevant in a time-constrained practice. In addition, it would be useful to know the utility of subjective memory questionnaires, activities of daily living screening instruments, and other noncognitively oriented instruments.
The studies discussed in this review are important only insofar as the ultimate detection of dementia proves to be beneficial. That is, if early cognitive decline can be arrested or reversed by therapeutic intervention, the value of these studies becomes apparent. In addition, the utility of counseling, assistance with decision making, driving, and legal, financial, and long-term care planning are all relevant issues. Because parallel work on the basic biology of dementing illnesses is progressing rapidly, it is incumbent upon clinical investigators to characterize these populations. When appropriate therapeutic interventions become available, clinical investigators will already have multiple, well characterized sets of subjects that would be amenable to treatment with these therapies.
The ultimate economic impact of this work is also significant. Because the segment of the population that is achieving the seventh and eighth decades of life is increasing at a rapid pace, the societal impact of dementing illnesses, which are strongly age-related, is large. There are additional considerations concerning quality of life, caregiver burden, health service utilization, institutionalization, and mortality that must be addressed.
Disclaimer. This statement is provided as an educational service of the American Academy of Neurology. It is based on an assessment of current scientific and clinical information. It is not intended to include all possible proper methods of care for a particular neurologic problem or all legitimate criteria for choosing to use specific procedures. Neither is it intended to exclude any reasonable alternative methodologies. The AAN recognizes that specific patient care decisions are the prerogative of the patient and the physician caring for the patient, based on all the circumstances involved.
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Appendix |
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Top.Article AbstractIntroductionClinical question statement.Process.Recommendations for future...AppendixReferences |
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Acknowledgments |
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Footnotes |
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The appointment of authors for this guideline was done in cooperation with the Alzheimer’s Association and overlaps significantly with the membership of the Medical and Scientific Advisory Council and the Board of Directors of the association. The Alzheimer’s Association agrees with the content of this paper in all important regards.
This guideline has been endorsed by the American Association of Neuroscience Nurses and the American Geriatrics Society.
Approved by the AAN Quality Standards Subcommittee November 11, 2000. Approved by the AAN Practice Committee January 6, 2001. Approved by the AAN Board of Directors February 24, 2001.
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Top.Article AbstractIntroductionClinical question statement.Process.Recommendations for future...AppendixReferences |
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B. Winblad, S. Gauthier, L. Scinto, H. Feldman, G. K. Wilcock, L. Truyen, A. J. Mayorga, D. Wang, H. R. Brashear, J. S. Nye, et al. Safety and efficacy of galantamine in subjects with mild cognitive impairment Neurology, May 27, 2008; 70(22): 2024 - 2035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chertkow MD, F. Massoud MD, Z. Nasreddine MD, S. Belleville PhD, Y. Joanette PhD, C. Bocti MD, V. Drolet BSc, J. Kirk MD, M. Freedman MD, and H. Bergman MD Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia Can. Med. Assoc. J., May 6, 2008; 178(10): 1273 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Holland, E. E. Smith, I. Csapo, M. E. Gurol, D. A. Brylka, R. J. Killiany, D. Blacker, M. S. Albert, C. R.G. Guttmann, and S. M. Greenberg Spatial Distribution of White-Matter Hyperintensities in Alzheimer Disease, Cerebral Amyloid Angiopathy, and Healthy Aging Stroke, April 1, 2008; 39(4): 1127 - 1133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Plassman, K. M. Langa, G. G. Fisher, S. G. Heeringa, D. R. Weir, M. B. Ofstedal, J. R. Burke, M. D. Hurd, G. G. Potter, W. L. Rodgers, et al. Prevalence of Cognitive Impairment without Dementia in the United States Ann Intern Med, March 18, 2008; 148(6): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. M. Brust A 74-Year-Old Man With Memory Loss and Neuropathy Who Enjoys Alcoholic Beverages JAMA, March 5, 2008; 299(9): 1046 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Raina, P. Santaguida, A. Ismaila, C. Patterson, D. Cowan, M. Levine, L. Booker, and M. Oremus Effectiveness of Cholinesterase Inhibitors and Memantine for Treating Dementia: Evidence Review for a Clinical Practice Guideline Ann Intern Med, March 4, 2008; 148(5): 379 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sundelof, V. Giedraitis, M. C. Irizarry, J. Sundstrom, E. Ingelsson, E. Ronnemaa, J. Arnlov, M. D. Gunnarsson, B. T. Hyman, H. Basun, et al. Plasma {beta} Amyloid and the Risk of Alzheimer Disease and Dementia in Elderly Men: A Prospective, Population-Based Cohort Study Arch Neurol, February 1, 2008; 65(2): 256 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Fleisher, S. Sun, C. Taylor, C. P. Ward, A. C. Gamst, R. C. Petersen, C. R. Jack Jr, P. S. Aisen, L. J. Thal, and For the Alzheimer's Disease Cooperative Study Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment Neurology, January 15, 2008; 70(3): 191 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Caselli and R. Yaari Medical Management of Frontotemporal Dementia American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 489 - 498. [Abstract] [PDF]
|
|
|
|
 |
|
 J. A. Lonie, L. L. Herrmann, C. L. Donaghey, and K. P. Ebmeier Clinical referral patterns and cognitive profile in mild cognitive impairment The British Journal of Psychiatry, January 1, 2008; 192(1): 59 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Garand, M. A. Dew, B. Urda, J. H. Lingler, S. T. DeKosky, and C. F. Reynolds Marital Quality in the Context of Mild Cognitive Impairment West J Nurs Res, December 1, 2007; 29(8): 976 - 992. [Abstract] [PDF]
|
|
|
|
|
|
C. Reitz, M.-X. Tang, J. Manly, R. Mayeux, and J. A. Luchsinger Hypertension and the Risk of Mild Cognitive Impairment Arch Neurol, December 1, 2007; 64(12): 1734 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Payot, J. Latour, F. Massoud, and M.-J. Kergoat Validation d'indicateurs de la prise en charge des atteintes des fonctions cognitives dans les unites d'evaluation geriatrique Can Fam Physician, November 1, 2007; 53(11): 1944 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. F. Boeve, M. H. Silber, C. B. Saper, T. J. Ferman, D. W. Dickson, J. E. Parisi, E. E. Benarroch, J. E. Ahlskog, G. E. Smith, R. C. Caselli, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease Brain, November 1, 2007; 130(11): 2770 - 2788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Alladi, J. Xuereb, T. Bak, P. Nestor, J. Knibb, K. Patterson, and J. R. Hodges Focal cortical presentations of Alzheimer's disease Brain, October 1, 2007; 130(10): 2636 - 2645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. deIpolyi, K. P. Rankin, L. Mucke, B. L. Miller, and M. L. Gorno-Tempini Spatial cognition and the human navigation network in AD and MCI Neurology, September 4, 2007; 69(10): 986 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Shan, Y. Chang, and C.-l. G. Lin Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression FASEB J, September 1, 2007; 21(11): 2753 - 2764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. T Kircher, S. Weis, K. Freymann, M. Erb, F. Jessen, W. Grodd, R. Heun, and D. T Leube Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding J. Neurol. Neurosurg. Psychiatry, August 1, 2007; 78(8): 812 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Royall, E. C. Lauterbach, D. Kaufer, P. Malloy, K. L. Coburn, K. J. Black, and The Committee on Research of the American Neuropsy The Cognitive Correlates of Functional Status: A Review From the Committee on Research of the American Neuropsychiatric Association J Neuropsychiatry Clin Neurosci, August 1, 2007; 19(3): 249 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. P. Nielsen, R. Ringstrom, E. H. Wiig, and L. Minthon Associations between AQT Processing Speed and Neuropsychological Tests in Neuropsychiatric Patients American Journal of Alzheimer's Disease and Other Dementias, July 1, 2007; 22(3): 202 - 210. [Abstract] [PDF]
|
|
|
|
|
|
W. R. Markesbery and M. A. Lovell Damage to Lipids, Proteins, DNA, and RNA in Mild Cognitive Impairment Arch Neurol, July 1, 2007; 64(7): 954 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Holsinger, J. Deveau, M. Boustani, and J. W. Williams Jr Does This Patient Have Dementia? JAMA, June 6, 2007; 297(21): 2391 - 2404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chen, E. M. Reiman, G. E. Alexander, R. J. Caselli, R. Gerkin, D. Bandy, A. Domb, D. Osborne, N. Fox, W. R. Crum, et al. Correlations Between Apolipoprotein E {epsilon}4 Gene Dose and Whole Brain Atrophy Rates Am J Psychiatry, June 1, 2007; 164(6): 916 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-C. Liu, P.-N. Wang, H.-C. Wang, K.-N. Lin, C.-J. Hong, C.-Y. Liu, and P.-H. Tsai Conversion to Dementia From Questionable Dementia in an Ethnic Chinese Population J Geriatr Psychiatry Neurol, June 1, 2007; 20(2): 76 - 83. [Abstract] [PDF]
|
|
|
|
 |
|
 S. L. Tyas, J. C. Salazar, D. A. Snowdon, M. F. Desrosiers, K. P. Riley, M. S. Mendiondo, and R. J. Kryscio Transitions to Mild Cognitive Impairments, Dementia, and Death: Findings from the Nun Study Am. J. Epidemiol., June 1, 2007; 165(11): 1231 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Kemppainen, S. Aalto, I. A. Wilson, K. Nagren, S. Helin, A. Bruck, V. Oikonen, M. Kailajarvi, M. Scheinin, M. Viitanen, et al. PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment Neurology, May 8, 2007; 68(19): 1603 - 1606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Fleisher, B. B. Sowell, C. Taylor, A. C. Gamst, R. C. Petersen, L. J. Thal, and for the Alzheimer's Disease Cooperative Study Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment Neurology, May 8, 2007; 68(19): 1588 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Slavin, C. K. Sandstrom, T.-T. T. Tran, P. M. Doraiswamy, and J. R. Petrella Hippocampal Volume and the Mini-Mental State Examination in the Diagnosis of Amnestic Mild Cognitive Impairment Am. J. Roentgenol., May 1, 2007; 188(5): 1404 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Luchsinger, C. Reitz, B. Patel, M.-X. Tang, J. J. Manly, and R. Mayeux Relation of Diabetes to Mild Cognitive Impairment Arch Neurol, April 1, 2007; 64(4): 570 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Lippa, J. E. Duda, M. Grossman, H. I. Hurtig, D. Aarsland, B. F. Boeve, D. J. Brooks, D. W. Dickson, B. Dubois, M. Emre, et al. DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers Neurology, March 13, 2007; 68(11): 812 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Devanand, G. Pradhaban, X. Liu, A. Khandji, S. De Santi, S. Segal, H. Rusinek, G. H. Pelton, L. S. Honig, R. Mayeux, et al. Hippocampal and entorhinal atrophy in mild cognitive impairment: Prediction of Alzheimer disease Neurology, March 13, 2007; 68(11): 828 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gliebus and C. F. Lippa The Influence of {beta}-Blockers on Delayed Memory Function in People With Cognitive Impairment American Journal of Alzheimer's Disease and Other Dementias, February 1, 2007; 22(1): 57 - 61. [Abstract] [PDF]
|
|
|
|
|
|
J. R. Criado, C. Amo, P. Quint, L. Kurelowech, and S. M. Otis Using Magnetoencephalography to Study Patterns of Brain Magnetic Activity in Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, January 1, 2007; 21(6): 416 - 423. [Abstract] [PDF]
|
|
|
|
|
|
C. DeCarli, G. B. Frisoni, C. M. Clark, D. Harvey, M. Grundman, R. C. Petersen, L. J. Thal, S. Jin, C. R. Jack Jr, P. Scheltens, et al. Qualitative Estimates of Medial Temporal Atrophy as a Predictor of Progression From Mild Cognitive Impairment to Dementia Arch Neurol, January 1, 2007; 64(1): 108 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Lingler, M. C. Nightingale, J. A. Erlen, A. L. Kane, C. F. Reynolds III, R. Schulz, and S. T. DeKosky Making Sense of Mild Cognitive Impairment: A Qualitative Exploration of the Patient's Experience Gerontologist, December 1, 2006; 46(6): 791 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Petersen Conversion. Neurology, November 14, 2006; 67(9 Suppl 3): S12 - S13. [Abstract] [Full Text]
|
|
|
|
|
|
V. Singh, H. Chertkow, J. P. Lerch, A. C. Evans, A. E. Dorr, and N. J. Kabani Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer's disease Brain, November 1, 2006; 129(11): 2885 - 2893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Saykin, H. A. Wishart, L. A. Rabin, R. B. Santulli, L. A. Flashman, J. D. West, T. L. McHugh, and A. C. Mamourian Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology, September 12, 2006; 67(5): 834 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Petersen and J. O'Brien Mild Cognitive Impairment Should Be Considered for DSM-V J Geriatr Psychiatry Neurol, September 1, 2006; 19(3): 147 - 154. [Abstract] [PDF]
|
|
|
|
|
|
D. Blacker and S. Lovestone Genetics and Dementia Nosology J Geriatr Psychiatry Neurol, September 1, 2006; 19(3): 186 - 191. [Abstract] [PDF]
|
|
|
|
|
|
P. A. Boyle, R. S. Wilson, N. T. Aggarwal, Y. Tang, and D. A. Bennett Mild cognitive impairment: Risk of Alzheimer disease and rate of cognitive decline Neurology, August 8, 2006; 67(3): 441 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Ready, B. R. Ott, and J. Grace Insight and cognitive impairment: effects on quality-of-life reports from mild cognitive impairment and Alzheimer's disease patients. American Journal of Alzheimer's Disease and Other Dementias, August 1, 2006; 21(4): 242 - 248. [Abstract] [PDF]
|
|
|
|
|
|
A. M. Murray, D. E. Tupper, D. S. Knopman, D. T. Gilbertson, S. L. Pederson, S. Li, G. E. Smith, A. K. Hochhalter, A. J. Collins, and R. L. Kane Cognitive impairment in hemodialysis patients is common. Neurology, July 25, 2006; 67(2): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Lippa and J. C. Morris Alzheimer neuropathology in nondemented aging: Keeping mind over matter Neurology, June 27, 2006; 66(12): 1801 - 1802. [Full Text] [PDF]
|
|
|
|
|
|
D. A. Bennett, J. A. Schneider, Z. Arvanitakis, J. F. Kelly, N. T. Aggarwal, R. C. Shah, and R. S. Wilson Neuropathology of older persons without cognitive impairment from two community-based studies Neurology, June 27, 2006; 66(12): 1837 - 1844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Marcos, P. Gil, A. Barabash, R. Rodriguez, M. Encinas, C. Fernandez, and J. A. Cabranes Neuropsychological Markers of Progression From Mild Cognitive Impairment to Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, May 1, 2006; 21(3): 189 - 196. [Abstract] [PDF]
|
|
|
|
|
|
R. C. Petersen, J. E. Parisi, D. W. Dickson, K. A. Johnson, D. S. Knopman, B. F. Boeve, G. A. Jicha, R. J. Ivnik, G. E. Smith, E. G. Tangalos, et al. Neuropathologic Features of Amnestic Mild Cognitive Impairment Arch Neurol, May 1, 2006; 63(5): 665 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Jicha, J. E. Parisi, D. W. Dickson, K. Johnson, R. Cha, R. J. Ivnik, E. G. Tangalos, B. F. Boeve, D. S. Knopman, H. Braak, et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol, May 1, 2006; 63(5): 674 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. W. Bokde, P. Lopez-Bayo, T. Meindl, S. Pechler, C. Born, F. Faltraco, S. J. Teipel, H.-J. Moller, and H. Hampel Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment Brain, May 1, 2006; 129(5): 1113 - 1124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Steffens, E. Otey, G. S. Alexopoulos, M. A. Butters, B. Cuthbert, M. Ganguli, Y. E. Geda, H. C. Hendrie, R. R. Krishnan, A. Kumar, et al. Perspectives on Depression, Mild Cognitive Impairment, and Cognitive Decline Arch Gen Psychiatry, February 1, 2006; 63(2): 130 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Gurol, M. C. Irizarry, E. E. Smith, S. Raju, R. Diaz-Arrastia, T. Bottiglieri, J. Rosand, J. H. Growdon, and S. M. Greenberg Plasma {beta}-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy Neurology, January 10, 2006; 66(1): 23 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Prohovnik, D. P. Perl, K. L. Davis, L. Libow, G. Lesser, and V. Haroutunian Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease Neurology, January 10, 2006; 66(1): 49 - 55. [Abstract] [Full Text] [PDF]
|
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|
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G. M. Doniger, T. Dwolatzky, D. M. Zucker, H. Chertkow, H. Crystal, A. Schweiger, and E. S. Simon Computerized cognitive testing battery identifies mild cognitive impairment and mild dementia even in the presence of depressive symptoms American Journal of Alzheimer's Disease and Other Dementias, January 1, 2006; 21(1): 28 - 36. [Abstract] [PDF]
|
|
|
|
|
|
P. A. Boyle, R. S. Wilson, N. T. Aggarwal, Z. Arvanitakis, J. Kelly, J. L. Bienias, and D. A. Bennett Parkinsonian signs in subjects with mild cognitive impairment Neurology, December 27, 2005; 65(12): 1901 - 1906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Irizarry, M. E. Gurol, S. Raju, R. Diaz-Arrastia, J. J. Locascio, M. Tennis, B. T. Hyman, J. H. Growdon, S. M. Greenberg, and T. Bottiglieri Association of homocysteine with plasma amyloid {beta} protein in aging and neurodegenerative disease Neurology, November 8, 2005; 65(9): 1402 - 1408. [Abstract] [Full Text] [PDF]
|
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|
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C. T. Gualtieri and L. G. Johnson Neurocognitive testing supports a broader concept of mild cognitive impairment American Journal of Alzheimer's Disease and Other Dementias, November 1, 2005; 20(6): 359 - 366. [Abstract] [PDF]
|
|
|
|
|
|
E van den Berg, R P C Kessels, E H F de Haan, L J Kappelle, and G J Biessels Mild impairments in cognition in patients with type 2 diabetes mellitus: the use of the concepts MCI and CIND J. Neurol. Neurosurg. Psychiatry, October 1, 2005; 76(10): 1466 - 1467. [Full Text] [PDF]
|
|
|
|
|
|
D. A. Fleischman, R. S. Wilson, J. D. E. Gabrieli, J. A. Schneider, J. L. Bienias, and D. A. Bennett Implicit memory and Alzheimer's disease neuropathology Brain, September 1, 2005; 128(9): 2006 - 2015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J D Fisk and K Rockwood Outcomes of incident mild cognitive impairment in relation to case definition J. Neurol. Neurosurg. Psychiatry, August 1, 2005; 76(8): 1175 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gauthier and J. Touchon Mild Cognitive Impairment Is Not a Clinical Entity and Should Not Be Treated Arch Neurol, July 1, 2005; 62(7): 1164 - 1166. [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Petersen, R. G. Thomas, M. Grundman, D. Bennett, R. Doody, S. Ferris, D. Galasko, S. Jin, J. Kaye, A. Levey, et al. Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment N. Engl. J. Med., June 9, 2005; 352(23): 2379 - 2388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Vandenberghe and J Tournoy Cognitive aging and Alzheimer's disease Postgrad. Med. J., June 1, 2005; 81(956): 343 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Stoub, M. Bulgakova, S. Leurgans, D. A. Bennett, D. Fleischman, D. A. Turner, and L. deToledo-Morrell MRI predictors of risk of incident Alzheimer disease: A longitudinal study Neurology, May 10, 2005; 64(9): 1520 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W Bondi Subjective memory deterioration in elderly people is associated with future dementia Evid. Based Ment. Health, May 1, 2005; 8(2): 47 - 47. [Full Text] [PDF]
|
|
|
|
|
|
J. N. Keller, F. A. Schmitt, S. W. Scheff, Q. Ding, Q. Chen, D. A. Butterfield, and W. R. Markesbery Evidence of increased oxidative damage in subjects with mild cognitive impairment Neurology, April 12, 2005; 64(7): 1152 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Bennett, J. A. Schneider, J. L. Bienias, D. A. Evans, and R. S. Wilson Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions Neurology, March 8, 2005; 64(5): 834 - 841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Ala, A. M. Popovich, and L. G. Berck Knowledge of personal information and caregiver awareness in Alzheimer's disease American Journal of Alzheimer's Disease and Other Dementias, March 1, 2005; 20(2): 119 - 125. [Abstract] [PDF]
|
|
|
|
|
|
M. W. Bondi, W. S. Houston, L. T. Eyler, and G. G. Brown fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease Neurology, February 8, 2005; 64(3): 501 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Nagahama, T Okina, N Suzuki, H Nabatame, and M Matsuda The cerebral correlates of different types of perseveration in the Wisconsin Card Sorting Test J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 169 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Tornatore, E. Hill, J. A. Laboff, and M. E. McGann Self-Administered Screening for Mild Cognitive Impairment: Initial Validation of a Computerized Test Battery J Neuropsychiatry Clin Neurosci, February 1, 2005; 17(1): 98 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Pennanen, C Testa, M P Laakso, M Hallikainen, E-L Helkala, T Hanninen, M Kivipelto, M Kononen, A Nissinen, S Tervo, et al. A voxel based morphometry study on mild cognitive impairment J. Neurol. Neurosurg. Psychiatry, January 1, 2005; 76(1): 11 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Solfrizzi, F. Panza, A. M. Colacicco, A. D'Introno, C. Capurso, F. Torres, F. Grigoletto, S. Maggi, A. Del Parigi, E. M. Reiman, et al. Vascular risk factors, incidence of MCI, and rates of progression to dementia Neurology, November 23, 2004; 63(10): 1882 - 1891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Elkins, E. S. O'Meara, W. T. Longstreth Jr., M. C. Carlson, T. A. Manolio, and S. C. Johnston Stroke risk factors and loss of high cognitive function Neurology, September 14, 2004; 63(5): 793 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Assini, S. Cammarata, A. Vitali, M. Colucci, L. Giliberto, R. Borghi, M. L. Inglese, S. Volpe, S. Ratto, F. Dagna-Bricarelli, et al. Plasma levels of amyloid {beta}-protein 42 are increased in women with mild cognitive impairment Neurology, September 14, 2004; 63(5): 828 - 831. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Luijpen, D. F. Swaab, J. A. Sergeant, and E. J. A. Scherder Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Self-Efficacy and Mood in Elderly with Mild Cognitive Impairment Neurorehabil Neural Repair, September 1, 2004; 18(3): 166 - 175. [Abstract] [PDF]
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