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Descending monoaminergic pain modulation

Bidirectional control and clinical relevance

From the Mayo Clinic, Department of Neurology, Rochester, MN.

Address correspondence and reprint requests to Dr. Eduardo E. Benarroch, Mayo Clinic, Department of Neurology, 200 First Street SW, West 8A Mayo Bldg, Rochester, MN 55905

GLOSSARY: CGRP = calcitonin gene-related peptide; DAT = dopamine transporter; GABA = -aminobutyric acid; NET = norepinephrine transporter; NRM = nucleus raphe magnus; PAG = periaqueductal gray; RLS = restless legs syndrome; RVMM = rostral ventromedial medulla; SERT = serotonin transporter; SNRI = serotonin and norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor; STT = spinothalamic tract.

benarroch.eduardo{at}mayo.edu

Disclosure: The author reports nodisclosures.

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