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Vanishing MS T2-bright lesions before puberty

A distinct MRI phenotype?

From UCSF Regional Pediatric Multiple Sclerosis Center (D.C., T.C.-T., E.M.M., J.B.S., E.W.), San Francisco; and Department of Radiology (O.A.G.), UCSF, San Francisco, CA.

Address correspondence and reprint requests to Dr. Dorothée Chabas, UCSF Regional Pediatric Multiple Sclerosis Center, 350 Parnassus Ave. Suite 908, San Francisco, CA 94117 Dorothee.Chabas{at}ucsf.edu

Background: Multiple sclerosis (MS) onset before puberty may have a distinct clinical presentation. Pediatric patients with MS may less often meet MRI diagnostic criteria for adults. Whether initial MRI presentation is distinct in prepubertal patients is unknown.

Methods: We queried the UCSF MS database for pediatric patients with MS (onset 18 years) who underwent brain MRI within 3 months of initial symptoms. The overall number of lesions and the number of well-defined and ovoid, large, confluent, and gadolinium-enhancing lesions were compared between patients with earlier-onset (EOPMS) (<11 years) and later-onset (LOPMS) (11 years) pediatric MS. The next available brain MRI scan was used to evaluate lesion resolution.

Results: Thirteen children with EOPMS (median age 8.90 years, range [3.58–10.98], 38% girls) and 18 with LOPMS (median age 14.47 years, range [11.78–18.00], 61% girls) were identified. While the overall number of T2-bright lesions was similar in the two groups, patients with EOPMS had fewer well-defined ovoid T2-bright lesions (median = 7, range [0–29] vs 21.5, [4–100]; p = 0.004) and more often had confluent lesions (31% of patients vs 0%; p = 0.02) on their first MRI compared with patients with LOPMS. Ninety-two percent of patients with EOPMS had a reduction in the number of T2-bright lesions on the second scan compared to 29% of patients with LOPMS (p = 0.002).

Conclusions: The distinct prepubertal multiple sclerosis (MS) MRI phenotype suggests that underlying biologic processes may differ in earlier-onset pediatric MS compared to later-onset pediatric MS. These findings may delay diagnosis in that age range. MRI criteria for MS diagnosis may need to be revised before puberty.

GLOSSARY: ADEM = acute disseminated encephalomyelitis; CIS = clinically isolated syndrome; EOPMS = earlier-onset pediatric MS; LOPMS = later-onset pediatric MS; MS = multiple sclerosis.

Supported by the National MS Society (The UCSF regional Pediatric MS clinic belongs to the Pediatric MS network initiated by the NMSS).

Disclosure: The authors report no disclosures.

Received December 18, 2007. Accepted in final form June 19, 2008.