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NEUROLOGY 2007;68:600-602
© 2007 American Academy of Neurology

Effect of referral bias on assessing survival in ALS

Eric J. Sorenson, MD, Jayawant Mandrekar, PhD, Brian Crum, MD and J. Clarke Stevens, MD

From the Departments of Neurology (E.J.S., B.C., J.C.S.) and Biostatistics (J.M.), Mayo Clinic, Rochester, MN.

Address correspondence and reprint requests to Dr. Eric J. Sorenson, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; e-mail: sorenson.eric{at}mayo.edu

We assessed the effect of referral bias on patients with ALS treated at our medical center. A total of 132 subjects were treated by our center over the past 3 years. The referral population had a median survival of 29 months compared to 18 months for the local population (p = 0.007). Referral bias should be addressed when assessing the efficacy of self-selected therapies in the setting of a tertiary ALS clinic.

Disclosure: The authors report no conflicts of interest.

Received July 7, 2006. Accepted in final form October 23, 2006.


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Correspondence:

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Effect of referral bias on assessing survival in ALS
Giancarlo Logroscino, et al.
Neurology Online, 24 May 2007 [Full text]
Reply from the Authors
Eric J. Sorenson, et al.
Neurology Online, 24 May 2007 [Full text]