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 Volume 68, Number 23, June 05, 2007
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NEUROLOGY 2007;68:2035-2038
© 2007 American Academy of Neurology

Prevalence of asymptomatic intracranial atherosclerosis in high-risk patients

K. S. Wong, MD, P. W. Ng, MD, A. Tang, MPhil, R. Liu, MPH, V. Yeung, MD and B. Tomlinson, MD

From the Departments of Medicine & Therapeutics (K.S.W., A.T., R.L., V.Y., B.T.), the Chinese University of Hong Kong, & Department of Medicine (P.W.N.), United Christian Hospital, Hong Kong SAR.

Address correspondence and reprint requests to Dr. Ka Sing Wong, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong ks-wong{at}cuhk.edu.hk

We used transcranial Doppler to screen 3,057 patients who had at least one vascular risk factor of hypertension, diabetes, or hyperlipidemia and found 385 (12.6%) had middle cerebral artery stenosis. Elderly, hypertension, diabetes, and hyperlipidemia were associated factors. The prevalence escalated quadratically with increasing number of associated factors: from 7.2% for one, to 29.6% for four associated factors. Asymptomatic middle cerebral artery stenosis is common in patients with vascular risk factors.

See also page 2031

Supported by Grant CUHK4280/97 from the Research Grant Council of the Research Grants Council of the University Grants Committee of Hong Kong. This project was awarded the Bruce S. Schoenberg International Award and Lecture in Neuroepidemiology by the American Academy of Neurology.

Disclosure: The authors report no conflicts of interest.

Received October 27, 2006. Accepted in final form February 5, 2007.


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