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Neurology supplements are not peer-reviewed. Information contained in Neurology supplements represent the opinions of the authors and are not endorsed by nor do they reflect the views of the American Academy of Neurology, Editor-in-Chief, or Associate Editors of Neurology.

Maintaining adherence and retention in dementia prevention trials

From the Alzheimer Disease Research Center, Department of Neurology, University of Pittsburgh, Pttsburgh, Pennsylvania.

Address correspondence to Dr. Steven T. DeKosky, Professor and Chair, Department of Neurology, Director, Alzheimer Disease Research Center, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213; e-mail: DeKoskyST{at}UPMC.edu

Incidence and prevalence of Alzheimer Disease (AD) will rise in a accelerating fashion through the middle of the 21^st century. Increased understanding of the pathological cascades in AD, and the knowledge that the initial brain changes begin years prior to clinical manifestations, have led to initiation of trials to prevent AD. With many of the designs being used or contemplated, prevention trials will involve repeated cognitive and functional assessments over years, require cooperation and collaboration of both the subject and a partner or proxy, and represent a substantial time and resource investment by the research team. Compliance with the study regimen and adherence to the protocol are thus major foci for study efficiency and success. In this section methods by which compliance and adherence can be optimized are discussed. Research on the effectiveness of these and other evolving methods will be of help in assuring success of such large scale studies in the future.

Publication of this supplement was supported by an educational grant from Beaufour Ipsen.

Disclosure: The sponsor has provided S.T.D. with an honorarium for his participation in this project and honoraria during his career.

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