Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takaya, S.
Right arrow Articles by Fukuyama, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takaya, S.
Right arrow Articles by Fukuyama, H.
Related Collections
Right arrow PET
Right arrow All Epilepsy/Seizures
Right arrow Functional neuroimaging
Right arrow PET in epilepsy
Right arrow Partial seizures
NEUROLOGY 2006;67:1674-1676
© 2006 American Academy of Neurology
Brief Communications

Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy

S. Takaya, MD, T. Hanakawa, MD, PhD, K. Hashikawa, MD, PhD, A. Ikeda, MD, PhD, N. Sawamoto, MD, PhD, T. Nagamine, MD, PhD, K. Ishizu, MD, PhD and H. Fukuyama, MD, PhD

From the Human Brain Research Center (S.T., T.H., K.H., N.S., T.N., H.F.), Department of Neurology (A.I.), and Department of Nuclear Medicine and Diagnostic Radiology (K.I.), Kyoto University Graduate School of Medicine, Kyoto, Japan.

Address correspondence and reprint requests to Dr. H. Fukuyama, Human Brain Research Center, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan; e-mail: fukuyama{at}bpp2.kuhp.kyoto-u.ac.jp

We compared the cognitive functions and interictal cerebral glucose metabolism of 11 patients with mesial temporal lobe epilepsy (MTLE) with frequent seizures to those of 10 patients with MTLE with rare seizures; the groups were matched for age, sex, education, IQ, and focus side. The frequent-seizure group had more set-shifting impairment that correlated with glucose hypometabolism in the prefrontal cortices. Our results suggest that frequent seizures in MTLE are associated with hypofunction of the prefrontal cortex.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 14 issue to find the title link for this article.

Disclosure: The authors report no conflicts of interest.

Received March 27, 2006. Accepted in final form July 17, 2006.




This article has been cited by other articles:


Home page
 BrainHome page
S. Takaya, N. Mikuni, T. Mitsueda, T. Satow, J. Taki, M. Kinoshita, S. Miyamoto, N. Hashimoto, A. Ikeda, and H. Fukuyama
Improved cerebral function in mesial temporal lobe epilepsy after subtemporal amygdalohippocampectomy
Brain, January 1, 2009; 132(1): 185 - 194.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.