Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Levchenko, A.
Right arrow Articles by Rouleau, G. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levchenko, A.
Right arrow Articles by Rouleau, G. A.
Related Collections
Right arrow Restless legs syndrome
Right arrow All Genetics
NEUROLOGY 2006;67:900-901
© 2006 American Academy of Neurology
Brief Communications

A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13

A. Levchenko, MSc, S. Provost, MSc, J. Y. Montplaisir, MD, PhD, L. Xiong, MD, PhD, J. St-Onge, DEC, P. Thibodeau, BSc, J. B. Rivière, BSc, A. Desautels, PhD, G. Turecki, MD, PhD, M. P. Dubé, PhD and G. A. Rouleau, MD, PhD

From the Center for the Study of Brain Diseases, CHUM Research Center–Notre Dame Hospital, Montreal, Quebec, Canada (A.L., L.X., J.S., P.T., J.-B.R., G.A.R.); Montreal Heart Institute Research Center, Montreal, Quebec, Canada (S.P., M.-P.D.); Sleep Disorders Center, Sacré-Coeur Hospital of Montreal, Quebec, Canada (J.-Y.M.); Research Center, Douglas Hospital, Verdun, Quebec, Canada (A.D., G.T.); and Department of Medicine, University of Montreal, Montreal, Quebec, Canada (M.-P.D., G.A.R.).

Address correspondence and reprint requests to Dr. Guy A. Rouleau, Center for the Study of Brain Diseases, CHUM Research Center–Notre Dame Hospital, J.A. de Sève Pavilion, Room Y-3633-1, 1560, Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada; e-mail: guy.rouleau{at}umontreal.ca.

The authors investigated genetic factors contributing to restless legs syndrome (RLS) by performing a 10-cM genome-wide scan in a large French-Canadian pedigree. They detected an autosomal-dominant locus mapping to chromosome 20p13, with a maximum multipoint lod score of 3.86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the September 12 issue to find the title link for this article.

This work was supported by the Canadian Institutes of Health Research with a grant (G.A.R., #MOP-64224) and the Canada Graduate Scholarships Doctoral Award (A.L.).

Disclosure: The authors report no conflicts of interest.

Received December 16, 2005. Accepted in final form May 9, 2006.




This article has been cited by other articles:


Home page
 J. Med. Genet.Home page
D Kemlink, O Polo, B Frauscher, V Gschliesser, B Hogl, W Poewe, P Vodicka, J Vavrova, K Sonka, S Nevsimalova, et al.
Replication of restless legs syndrome loci in three European populations
J. Med. Genet., May 1, 2009; 46(5): 315 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
J. E. Young, C. Vilarino-Guell, S.-C. Lin, Z. K. Wszolek, and M. J. Farrer
Clinical and Genetic Description of a Family With a High Prevalence of Autosomal Dominant Restless Legs Syndrome
Mayo Clin. Proc., February 1, 2009; 84(2): 134 - 138.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. Lohmann-Hedrich, A. Neumann, A. Kleensang, T. Lohnau, H. Muhle, A. Djarmati, I. R. Konig, P. P. Pramstaller, E. Schwinger, P. L. Kramer, et al.
Evidence for linkage of restless legs syndrome to chromosome 9p: Are there two distinct loci?
Neurology, February 26, 2008; 70(9): 686 - 694.
[Abstract] [Full Text] [PDF]