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fMRI reveals novel functional neuroanatomy in a child with perinatal stroke

From the Departments of Psychology (T.T.B., S.E.P.), Neurology (D.A.F., T.T.B., S.E.P., B.L.S.) Radiology (S.E.P., B.L.S.), Department of Anatomy and Neurobiology (S.E.P., B.L.S.), and Pediatrics (B.L.S.), Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Damien Fair, PA-C, Department of Neurology, Campus Box 8111, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110; e-mail: damien.fair{at}wustl.edu

Children who have experienced a perinatal stroke often develop normal language function, but the neurobiologic mechanisms underlying this plasticity remain unclear. In this study, we used fMRI to compare, at two ages, the functional neuroanatomy of a child with perinatal stroke with that of age-appropriate cohorts of typically developing children. Although the data for this child are similar to the control group, there are age-dependent differences.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 26 issue to find the link for this article.

This work was supported in part by the Washington University Chancellor’s Fellowship and UNCF * Merck Graduate Science Research Dissertation Fellowship (D.A.F.) and by NIH NSADA (B.L.S.), NS32979 (S.E.P.), NS41255 (S.E.P.), NS46424 (S.E.P.), The McDonnell Center for Higher Brain function (S.E.P., B.L.S.), and The Charles A. Dana Foundation (B.L.S.).

Disclosure: The authors report no conflicts of interest

Received April 19, 2006. Accepted in final form September 5, 2006.

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