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© 2006 American Academy of Neurology Dissociating apathy and depression in Parkinson diseaseFrom the Department of Clinical and Health Psychology (L.K.-D., M.M., D.B.), College of Public Health and Health Professions, and Department of Neurology (H.F.F., M.S.O., D.B.), College of Medicine, University of Florida, Gainesville. Address correspondence and reprint requests to L. Kirsch-Darrow, Department of Clinical and Health Psychology, University of Florida, 1600 SW Archer Rd., PO Box 100165, Gainesville, FL 32608; e-mail: lkirsch{at}phhp.ufl.edu Objective: To examine the hypothesis that apathy is a core feature of Parkinson disease (PD) and that apathy can be dissociated from depression. Methods: Eighty patients with PD and 20 patients with dystonia completed depression and apathy measures including the Marin Apathy Evaluation Scale (AES), Beck Depression Inventory (BDI), and Centers for Epidemiologic Studies–Depression Scale (CES-D). Results: There was a significantly higher severity and frequency of apathy in PD (frequency = 51%, 41/80) than in dystonia (frequency = 20%, 4/20). Apathy in the absence of depression was frequent in PD and did not occur in dystonia (PD = 28.8%, dystonia = 0%). Conclusions: Patients with Parkinson disease (PD) experienced significantly higher frequency and severity of apathy when compared with patients with dystonia. Apathy may be a "core" feature of PD and occurs in the absence of depression.
Editorial, see page 10 Supported by a National Parkinson’s Foundation Center of Excellence grant and NIH grant to M.S.O. (K23 NS044997-01A1) and NIH grants to D.B. (R01 MH62539 and R01 NS50633). Disclosure: The authors report no conflicts of interest. Received September 23, 2005. Accepted in final form April 17, 2006.
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