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NEUROLOGY 2006;67:161-163
© 2006 American Academy of Neurology
Brief Communications

Grading cervical cord damage in neuromyelitis optica and MS by diffusion tensor MRI

B. Benedetti, MD, P. Valsasina, PhD, E. Judica, MD, V. Martinelli, MD, A. Ghezzi, MD, R. Capra, MD, R. Bergamaschi, MD, G. Comi, MD and M. Filippi, MD

From Neuroimaging Research Unit (B.B., P.V., E.J., M.F.), Department of Neurology (B.B., E.J., V.M., G.C., M.F.), Scientific Institute and University Ospedale San Raffaele, Milan, Italy; Multiple Sclerosis Center (A.G.), Ospedale di Gallarate, Gallarate, Italy; Department of Neurology (R.C.), Spedali Civili, University of Brescia, Brescia, Italy; Department of Neurological Sciences (R.B.), Scientific Institute C. Mondino, University of Pavia, Pavia, Italy.

Address correspondence and reprint requests to Dr. Massimo Filippi, Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina, 60, 20132 Milan, Italy; e-mail: m.filippi{at}hsr.it

The authors assessed the ability of diffusion tensor MRI to grade cervical cord damage in 10 patients with neuromyelitis optica, 10 patients with multiple sclerosis, and 10 healthy controls. The three groups differed in terms of average mean diffusivity (p = 0.008) and average fractional anisotropy (p = 0.04). There was a correlation between the Expanded Standard Disability Status Scale score and cord average mean diffusivity (r = 0.52, p = 0.02).

Disclosure: The authors report no conflicts of interest.

Received December 14, 2005. Accepted in final form March 14, 2006.




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