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Published online before print December 28, 2005, doi:10.1212/01.wnl.0000195887.63124.dc)
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Volume 66, Number 3, February 14, 2006
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NEUROLOGY 2006;66:436-438
© 2006 American Academy of Neurology


Brief Communications

Albendazole trial at 15 or 30 mg/kg/day for subarachnoid and intraventricular cysticercosis

F. Göngora-Rivera, MD, J. L. Soto-Hernández, MD, D. González Esquivel, MS, H. J. Cook, PhD, C. Márquez-Caraveo, MD, R. Hernández Dávila, MD and J. Santos-Zambrano, MD

From the Department of Neurology (F.R-G., C.M.-C., R.H.D., J.S.-Z.), Department of Infectious Diseases (J.L.S.-H.), and Neuropharmacology Laboratory (D.G.E., H.J.C.), Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, Mexico.

Address correspondence and reprint requests to Dr. José Luis Soto-Hernández, Department of Infectious Disease, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Insurgentes Sur 3877, Tlalpan 14269, D.F., Mexico City, Mexico; e-mail: joseluis_sotohernandez{at}yahoo.com

Thirty-six patients with subarachnoid and intraventricular cysticercosis were randomly assigned to receive albendazole at 15 or 30 mg/kg/day plus dexamethasone for 8 days. Results favored a higher dose, with larger cyst reduction on MRI at 90 and 180 days and higher albendazole sulfoxide levels in plasma. An albendazole course at 30 mg/kg/day combined with corticosteroids is safe and more effective than the usual dose. A single treatment was insufficient in intraventricular and giant cysts.


Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the February 14 issue to find the title link for this article.

This article was previously published in electronic format as an Expedited E-Pub on December 28, 2005, atwww.neurology.org.

Disclosure: The authors report no conflicts of interest.

Received May 16, 2005. Accepted in final form October 27, 2005.




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