| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Department of Molecular Biology and Biochemistry, University of California, Irvine, CA.
Address correspondence and reprint requests to Dr. Charles G. Glabe, Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697; e-mail: cglabe{at}uci.edu
Recent findings indicate that soluble amyloid oligomers may represent the primary pathologic species in degenerative diseases. These amyloid oligomers share common structural features and the ability to permeabilize membranes, suggesting that they also share a common primary mechanism of pathogenesis. Membrane permeabilization by amyloid oligomers may initiate a common group of downstream pathologic processes, including intracellular calcium dyshomeostasis, production of reactive oxygen species, altered signaling pathways, and mitochondrial dysfunction that represent key effectors of cellular dysfunction and cell death in amyloid-associated degenerative disease, such as sporadic inclusion-body myositis.
This article was previously published in electronic format as an Expedited E-Pub at www.neurology.org.
Disclosure: C.G. and R.K. are consultants for Kinexis, Inc., receiving personal compensation in excess of $10,000/year.
Received June 22, 2005. Accepted in final form October 14, 2005.
This article has been cited by other articles:
|
|
 |
|
  S. Wray and W. Noble Linking Amyloid and Tau Pathology in Alzheimer's Disease: The Role of Membrane Cholesterol in A{beta}-Mediated Tau Toxicity J. Neurosci., August 5, 2009; 29(31): 9665 - 9667. [Full Text] [PDF]
|
|
|
|
 |
|
 S. A Greenberg How citation distortions create unfounded authority: analysis of a citation network BMJ, July 23, 2009; 339(jul20_3): b2680 - b2680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Deshpande, H. Kawai, R. Metherate, C. G. Glabe, and J. Busciglio A Role for Synaptic Zinc in Activity-Dependent A{beta} Oligomer Formation and Accumulation at Excitatory Synapses J. Neurosci., April 1, 2009; 29(13): 4004 - 4015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Rose, L. Crews, E. Rockenstein, A. Adame, M. Mante, L. B. Hersh, F. H. Gage, B. Spencer, R. Potkar, R. A. Marr, et al. Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease J. Neurosci., January 28, 2009; 29(4): 1115 - 1125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Pattison, A. Sanbe, A. Maloyan, H. Osinska, R. Klevitsky, and J. Robbins Cardiomyocyte Expression of a Polyglutamine Preamyloid Oligomer Causes Heart Failure Circulation, May 27, 2008; 117(21): 2743 - 2751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kostka, T. Hogen, K. M. Danzer, J. Levin, M. Habeck, A. Wirth, R. Wagner, C. G. Glabe, S. Finger, U. Heinzelmann, et al. Single Particle Characterization of Iron-induced Pore-forming {alpha}-Synuclein Oligomers J. Biol. Chem., April 18, 2008; 283(16): 10992 - 11003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Soto and L. D. Estrada Protein Misfolding and Neurodegeneration Arch Neurol, February 1, 2008; 65(2): 184 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fonte, D. R. Kipp, J. Yerg III, D. Merin, M. Forrestal, E. Wagner, C. M. Roberts, and C. D. Link Suppression of in Vivo -Amyloid Peptide Toxicity by Overexpression of the HSP-16.2 Small Chaperone Protein J. Biol. Chem., January 11, 2008; 283(2): 784 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-j. Huang, L. Haataja, T. Gurlo, A. E. Butler, X. Wu, W. C. Soeller, and P. C. Butler Induction of endoplasmic reticulum stress-induced -cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1656 - E1662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Stutzmann The Pathogenesis of Alzheimers Disease Is It a Lifelong "Calciumopathy"? Neuroscientist, October 1, 2007; 13(5): 546 - 559. [Abstract] [PDF]
|
|
|
|
|
|
S. F. de Almeida, G. Picarote, J. V. Fleming, M. Carmo-Fonseca, J. E. Azevedo, and M. de Sousa Chemical Chaperones Reduce Endoplasmic Reticulum Stress and Prevent Mutant HFE Aggregate Formation J. Biol. Chem., September 21, 2007; 282(38): 27905 - 27912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-Y. Lin, T. Gurlo, R. Kayed, A. E. Butler, L. Haataja, C. G. Glabe, and P. C. Butler Toxic Human Islet Amyloid Polypeptide (h-IAPP) Oligomers Are Intracellular, and Vaccination to Induce Anti-Toxic Oligomer Antibodies Does Not Prevent h-IAPP-Induced {beta}-Cell Apoptosis in h-IAPP Transgenic Mice Diabetes, May 1, 2007; 56(5): 1324 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhao, Y. Fu, M. Yasvoina, P. Shao, B. Hitt, T. O'Connor, S. Logan, E. Maus, M. Citron, R. Berry, et al. {beta}-Site Amyloid Precursor Protein Cleaving Enzyme 1 Levels Become Elevated in Neurons around Amyloid Plaques: Implications for Alzheimer's Disease Pathogenesis J. Neurosci., April 4, 2007; 27(14): 3639 - 3649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, D. R. Smith, J. W. Jones, and M. R. Chapman In Vitro Polymerization of a Functional Escherichia coli Amyloid Protein J. Biol. Chem., February 9, 2007; 282(6): 3713 - 3719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rockabrand, N. Slepko, A. Pantalone, V. N. Nukala, A. Kazantsev, J. L. Marsh, P. G. Sullivan, J. S. Steffan, S. L. Sensi, and L. M. Thompson The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis Hum. Mol. Genet., January 1, 2007; 16(1): 61 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang and J. Robbins Heart Failure and Protein Quality Control Circ. Res., December 8, 2006; 99(12): 1315 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Meier, R. Kayed, C.-Y. Lin, T. Gurlo, L. Haataja, S. Jayasinghe, R. Langen, C. G. Glabe, and P. C. Butler Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1317 - E1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhu, Y. Lai, P. B. Shelat, C. Hu, G. Y. Sun, and J. C-M. Lee Phospholipases A2 Mediate Amyloid-beta Peptide-Induced Mitochondrial Dysfunction J. Neurosci., October 25, 2006; 26(43): 11111 - 11119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Meyer-Luehmann, J. Coomaraswamy, T. Bolmont, S. Kaeser, C. Schaefer, E. Kilger, A. Neuenschwander, D. Abramowski, P. Frey, A. L. Jaton, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science, September 22, 2006; 313(5794): 1781 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Ehrnhoefer, M. Duennwald, P. Markovic, J. L. Wacker, S. Engemann, M. Roark, J. Legleiter, J. L. Marsh, L. M. Thompson, S. Lindquist, et al. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models Hum. Mol. Genet., September 15, 2006; 15(18): 2743 - 2751. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Finch A perspective on sporadic inclusion-body myositis: The role of aging and inflammatory processes Neurology, January 24, 2006; 66(1_suppl_1): S1 - S6. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Engel and V. Askanas Inclusion-body myositis: Clinical, diagnostic, and pathologic aspects Neurology, January 24, 2006; 66(1_suppl_1): S20 - S29. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
