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NEUROLOGY 2005;65:1322-1324
© 2005 American Academy of Neurology
Brief Communications

Large cerebral artery involvement in CADASIL

Eun J. Choi, MD, Choong G. Choi, MD and Jong S. Kim, MD

From the Department of Neurology (Dr Choi), University of Korea College of Medicine, Guro Hospital, Departments of Radiology (Dr. C.G. Choi) and Neurology (Dr. Kim), University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Address correspondence and reprint requests to Dr. Jong S. Kim, Department of Neurology, Asan Medical Center, 388-1, Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea; e-mail: jongskim{at}amc.seoul.kr

The authors evaluated the involvement of large cerebral artery in 13 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with angiography (12 MR and one conventional). Five patients (38%) showed stenosis: at the middle cerebral artery in three, vertebral artery in one, and the internal carotid artery in one. The stenosis persisted on follow-up angiogram in two patients. There were no differences in risk factors between patients with angiographic abnormality and those without, suggesting occasional involvement of large vessels in CADASIL.

Supported by a grant (M103KV010005 03K2201 00540) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology.

Disclosure: The authors report no conflicts of interest.

Received February 22, 2005. Accepted in final form July 6, 2005.




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[Abstract] [Full Text] [PDF]


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