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Transverse sinus stenoses persist after normalization of the CSF pressure in IIH

From the Institutes of Neurology (Drs. Bono, Giliberto, Mastrandrea, Cristiano, and Quattrone) and Neurosurgery (Dr. Lavano), University Magna Græcia, Catanzaro, and Institute of Neurological Sciences (Drs. Fera, Quattrone), National Research Council, Piano Lago di Mangone, Cosenza, Italy.

Address correspondence and reprint requests to Prof. A. Quattrone, Clinica Neurologica, Policlinico MaterDomini, Via T. Campanella, 88100 Catanzaro, Italy; e-mail: a.quattrone{at}isn.cnr.it

Background: Bilateral transverse sinus (TS) stenosis has been found in more than 90% of patients with idiopathic intracranial hypertension (IIH).

Objective: To evaluate whether TS stenosis changed after normalization of CSF pressure in patients with IIH during medical treatment.

Methods: Fourteen consecutive patients with IIH with bilateral TS stenosis on cerebral MR venography (MRV) during the medical treatment were studied. Patients were followed for over a 6-year period. During the follow-up, patients underwent repeated lumbar punctures (LPs) and cerebral MRV. MRV was always performed before each LP.

Results: TS stenosis persisted in all the patients during the follow-up. In 9 of 14 (64%) patients with IIH, CSF pressure normalized during medical treatment.

Conclusions: Transverse sinus (TS) stenoses, as revealed by MR venography, persist in patients with idiopathic intracranial hypertension after normalization of CSF pressure, suggesting the lack of a direct relationship between the caliber of TS and CSF pressure.

Disclosure: The authors report no conflicts of interest.

Received January 14, 2005. Accepted in final form June 22, 2005.

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