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 Volume 65, Number 3, August 09, 2005
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NEUROLOGY 2005;65:456-458
© 2005 American Academy of Neurology
Brief Communications

Polyneuropathy associated with interferon beta treatment in patients with multiple sclerosis

Dana Ekstein, MD, Eduard Linetsky, MD, Oded Abramsky, MD, PhD and Dimitrios Karussis, MD, PhD

From the Department of Neurology and the Agnes Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Ein-Karem, Jerusalem, Israel.

Address correspondence and reprint requests to Dr. Dana Ekstein, Department of Neurology, Hadassah-Hebrew University Hospital, P.O. Box 12000, Ein-Karem, Jerusalem, 91120, Israel; e-mail: dekstein{at}md.huji.ac.il

Peripheral neuropathy has been reported as a side effect of interferon alpha, but not with interferon beta (IFNß) treatment. The authors assessed six patients with multiple sclerosis who developed polyneuropathy, or had exacerbation of previously subclinical neuropathy, during treatment with IFNß. In five patients the neuropathy improved after discontinuation of treatment and in two patients it relapsed upon rechallenge.

Supported by the Hilda Katz Blaustein Fund for Research in Neurology.

Disclosure: The authors report no conflicts of interest.

Received October 21, 2004. Accepted in final form April 18, 2005.


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Correspondence:

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Polyneuropathy associated with interferon beta treatment in patients with multiple sclerosis
Bernd C. Kieseier, et al.
Neurology Online, 19 Oct 2005 [Full text]
Reply to Kieseier et al
Dana Ekstein, et al.
Neurology Online, 19 Oct 2005 [Full text]