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NEUROLOGY 2005;64:1641-1643
© 2005 American Academy of Neurology
Brief Communications

Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis

J. M. Ponseti, MD, PhD, J. Azem, MD, J. M. Fort, MD, PhD, M. López-Cano, MD, PhD, R. Vilallonga, MD, M. Buera, MD, C. Cervera, MD, PhD and M. Armengol, MD, PhD

From the Myasthenia Gravis Unit, Department of Surgery (Drs. Ponseti, Azem, Fort, López-Cano, Vilallonga, Buera, and Armengol) and Neurology Service (Dr. Cervera), Hospital General Universitari Vall d’Hebron, Autonomous University of Barcelona, Barcelona, Spain.

Address correspondence and reprint requests to Dr. José M. Ponseti, Unit of Myasthenia Gravis, Department of Surgery, Hospital General Universitari Vall d’Hebron, Passeig Vall d’Hebron 119-129, E-08035 Barcelona, Spain; e-mail: jmponseti{at}vhebron.net and 5012jpb{at}comb.es

Seventy-nine patients with cyclosporine- and prednisone-dependent myasthenia gravis (MG) after thymectomy received tacrolimus for a mean of 2.5 ± 0.8 years. Prednisone was withdrawn in all but two patients. Anti-acetylcholine antibodies and MG score for disease severity decreased significantly and muscular strength increased by 39%. Complete stable remission was achieved in 5% of patients and pharmacologic remission in 87.3%. All patients resumed full activities of daily living.

Received October 28, 2004. Accepted in final form January 26, 2005.


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D. B. Sanders, J. A. Aarli, G. R. Cutter, A. Jaretzki III, H. J. Kaminski, L. H. Phillips II, J .M. Ponseti, J . Azem, J .M. Fort, M . Lopez-Cano, et al.
Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis
Neurology, March 28, 2006; 66(6): 954 - 955.
[Full Text] [PDF]

Correspondence:

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Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis
Donald B. Sanders, et al.
Neurology Online, 15 Sep 2005 [Full text]
Reply to Sanders et al
José M. Ponseti, et al.
Neurology Online, 15 Sep 2005 [Full text]