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NEUROLOGY 2005;64:746-750
© 2005 American Academy of Neurology
Brief Communications

Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms

R. Jonas, MD, R. F. Asarnow, PhD, C. LoPresti, PhD, S. Yudovin, RN, MN, PNP, S. Koh, MD, J. Y. Wu, MD, R. Sankar, MD, PhD, W. D. Shields, MD, H. V. Vinters, MD, FRCP(C), FCAP and G. W. Mathern, MD

From the Divisions of Neurosurgery (Dr. Mathern), Pediatric Neurology (Drs. Jonas, Koh, Wu, Sankar, and Shields, S. Yudovin), Neuropathology (Dr. Vinters), and Departments of Neurology (Drs. Shields and Vinters), and Psychiatry and Biobehavioral Sciences (Drs. Asarnow and LoPresti), The Brain Research Institute (Drs. Shields, Vinters, and Mathern) and The Mental Retardation Research Center (Drs. Asarnow, Shields, Vinters, and Mathern); David Geffen School of Medicine; University of California, Los Angeles.

Address correspondence and reprint requests to Dr. Gary W. Mathern, Reed Neurologic Research Center, 710 Westwood Plaza, Rm 2123, Los Angeles, CA 90095-1769; e-mail: gmathern{at}ucla.edu

Children undergoing surgery with infant-onset epilepsy were classified into those with medically refractory infantile spasms (IS), successfully treated IS, and no IS history, and the groups were compared for pre- and postsurgery clinical and Vineland Adaptive Behavior Scale (VABS) developmental quotients (DQ). Children without an IS history were older at surgery and had longer epilepsy durations than those with IS despite similar substrates, surgeries, and seizure frequencies. In all groups, better postsurgery VABS-DQ scores were associated with early surgical intervention indicating that infant-onset epilepsy patients with or without IS are at risk for seizure-induced encephalopathy.


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