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A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines

From the Departments of Emergency Medicine (Drs. Friedman, Corbo, Bijur, Esses, and Gallagher), Neurology (Dr. Lipton), and Epidemiology and Population Health (Drs. Lipton, Bijur, and Gallagher), Albert Einstein College of Medicine, and Pharmacy Department (Dr. Solorzano), Montefiore Medical Center, Bronx, NY.

Address correspondence and reprint requests to Dr. B.W. Friedman, Department of Emergency Medicine, Montefiore Medical Center, 111 E. 210 St., Bronx, NY 10467; e-mail: befriedm{at}montefiore.org

Objective: To compare the efficacy of 20 mg of IV metoclopramide, given up to four times over 2 hours as needed for persistent headache, with 6 mg of subcutaneous sumatriptan for the emergency department treatment of migraine headaches.

Methods: This was a randomized, double-blind, clinical trial with two intervention arms. The primary endpoint was change in pain intensity as measured by an 11-point pain scale at 2 hours. Secondary endpoints included change in pain intensity at 24 hours and rates of pain-free headache relief at 2 and 24 hours.

Results: Two hundred two patients were screened, and 78 of 91 eligible patients were randomized. The two groups had comparable pain scores at baseline. By 2 hours, the change in pain intensity for the metoclopramide group was 7.2 compared with 6.3 for the sumatriptan group (95% CI for difference: –0.2 to 2.2). When compared at 24 hours, the metoclopramide group had improved by 6.1 compared with baseline and the sumatriptan group had improved by 5.0 (95% CI for difference: –0.6 to 2.8). At 2 hours, pain-free rates were 59% in the metoclopramide arm and 35% in the sumatriptan arm (95% CI for difference of 24%: 2 to 46%). The most common side effects at both time points were weakness, dizziness, and drowsiness, which were distributed evenly between the two groups. There were no reports of chest pain within the first 2 hours. The incidence of restlessness, stiffness, and abnormal movements was distributed equally between the two groups.

Conclusions: When compared at 2 and 24 hours, aggressive (20 mg dosed up to four times) IV metoclopramide and 6 mg of subcutaneous sumatriptan relieved migraine headache pain comparably. Some secondary endpoints suggest that metoclopramide may be the preferable therapy for migraines presenting to the emergency department.

Received July 8, 2004. Accepted in final form October 22, 2004.

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This article has been cited by other articles:

				B. W. Friedman, P. Greenwald, T. C. Bania, D. Esses, M. Hochberg, C. Solorzano, J. Corbo, J. Chu, E. Chew, P. Cheung, et al. Randomized trial of IV dexamethasone for acute migraine in the emergency department Neurology, November 27, 2007; 69(22): 2038 - 2044. [Abstract] [Full Text] [PDF]

				S. R. Brenner, M. Allena, D. Magis, J. Schoenen, B.W. Friedman, J. Corbo, R.B. Lipton, P.E. Bijur, D. Esses, and E.J. Gallagher A trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines Neurology, October 25, 2005; 65(8): 1339 - 1340. [Full Text] [PDF]

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