Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paleacu, D.
Right arrow Articles by Inzelberg, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paleacu, D.
Right arrow Articles by Inzelberg, R.
Related Collections
Right arrow Parkinson's disease/Parkinsonism
Right arrow Hallucinations
Right arrow Parkinson's disease with dementia
NEUROLOGY 2005;64:1712-1715
© 2005 American Academy of Neurology

Association between family history of dementia and hallucinations in Parkinson disease

Diana Paleacu, MD, Edna Schechtman, PhD and Rivka Inzelberg, MD

From the Neurology Service and Memory Clinic (Dr. Paleacu), Yehuda Abarbanel Mental Health Center and Sackler Faculty of Medicine, Tel-Aviv University, Industrial Engineering (Dr. Schechtman), Ben Gurion University, Beer Sheva, Department of Neurology (Dr. Inzelberg), Hillel Yaffe Medical Center, Hadera, and Bruce Rappaport Faculty of Medicine (Dr. Inzelberg), Technion, Haifa, Israel.

Address correspondence and reprint requests to Dr. R. Inzelberg, Department of Neurology, Hillel Yaffe Medical Center, Hadera, 38100, Israel; e-mail: irivka{at}tx.technion.ac.il

Objective: To identify familial risk factors for hallucinations in patients with Parkinson disease (PD).

Methods: Two hundred seventy-six outpatients with PD participated in the study. The presence of hallucinations was determined using a validated questionnaire, including items regarding the occurrence of visual, auditory, or other types of hallucinations. Family history of PD and dementia was determined by a structured interview and examination of medical records and affected family members. Patients with young-onset PD (<50 years) who reported another PD patient among their siblings were tested for parkin mutations. Stepwise logistic regression was applied for the detection of risk factors. The regression model included a set of family history–related variables (family history of PD and of dementia) and a set of disease-related variables (age, age at onset of PD, stage, duration of PD and of l-dopa therapy, l-dopa dose, and number of antiparkinsonian drugs).

Results: Hallucinations were present in 32% of the 276 patients. Risk factors for hallucinations included Mini-Mental State Examination score (p < 0.0001) and positive family history of dementia (p = 0.0005).

Conclusion: Family history of dementia and lower Mini-Mental State Examination scores are risk factors for hallucinations in Parkinson disease.

Presented in preliminary form at the American Academy of Neurology meeting, San Francisco, CA, 2004.

Received July 7, 2004. Accepted in final form January 25, 2005.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by AAN Enterprises, Inc.