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 Volume 63, Number 6, September 28, 2004
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NEUROLOGY 2004;63:1079-1080
© 2004 American Academy of Neurology
Brief Communications

The bioavailability of IV methylprednisolone and oral prednisone in multiple sclerosis

S. A. Morrow, MD, C. A. Stoian, MD MSc, J. Dmitrovic, MSc, S. C. Chan, PhD and L. M. Metz, MD FRCPC

From the Department of Clinical Neurosciences (Dr. Morrow), University of Western Ontario, London, Ontario; and the Department of Clinical Neurosciences (Drs. Stoian and Metz) and Departments of Pharmacology and Therapeutics/Pathology and Laboratory Medicine (Mr. Dmitrovic and Dr. Chan), University of Calgary, Calgary, Alberta, Canada.

Address correspondence and reprint requests to Dr. Luanne Metz, Foothills Hospital, 1403–29th Street NW, Calgary, Alberta, T2N 2T9; e-mail: lmetz{at}ucalgary.ca

Oral prednisone 1might be a convenient, inexpensive alternative to IV methylprednisolone (IVMP) if the bioequivalent dose was known. We compared the total amount of steroid absorbed after 1250 mg oral prednisone vs 1 gram IVMP in 16 patients with multiple sclerosis (MS). At 24 hours, the mean area under the concentration-time curve (AUC), the main component of bioavailability, did not differ between groups (p = 0.122). This suggests that the amount of absorbed corticosteroid is similar after either steroid at these doses.

Received April 7, 2004. Accepted in final form June 9, 2004.

See Commentary, page 945


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September 28 Highlight and Commentary
Neurology 2004 63: 945. [Full Text] [PDF]



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Correspondence:

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The bioavailability of IV methylprednisolone and oral prednisone in multiple sclerosis
Michael Strupp
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Reply to Strupp
Luanne M Metz
Neurology Online, 18 Nov 2004 [Full text]