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NEUROLOGY 2004;63:359-361
© 2004 American Academy of Neurology
Brief Communications

DD genotype of ACE gene is a risk factor for intracerebral hemorrhage

A. Slowik, MD, W. Turaj, MD, T. Dziedzic, MD, A. Haefele, BS, J. Pera, MD, M. T. Malecki, MD, L. Glodzik-Sobanska, MD, P. Szermer, MD, D. A. Figlewicz, PhD and A. Szczudlik, MD PhD

From the Departments of Neurology (Drs. Slowik, Turaj, Dziedzic, Pera, Glodzik-Sobanska, Szermer, and Szczudlik) and Metabolic Diseases (Dr. Malecki), Jagiellonian University, Medical College, Krakow, Poland; and the Department of Neurology (A. Haefele and Dr. Figlewicz), University of Rochester, NY. D.A.F. is currently affiliated with the Department of Neurology, University of Michigan, Ann Arbor; A.H. is currently affiliated with the Department of Biochemistry and Molecular Biology, State University of New York, Upstate Medical University, Syracuse.

Address correspondence and reprint requests to Dr. Agnieszka Slowik, Department of Neurology, Jagiellonian University, 31-503 Krakow, Botaniczna 3, Poland; e-mail: slowik{at}neuro.cm-uj.krakow.pl

Genetic factors may play a role in susceptibility to stroke. The angiotensin converting enzyme (ACE) gene is a candidate gene for two phenotypically different types of stroke affecting small perforating arteries: spontaneous intracerebral hemorrhage (SIH) and ischemic stroke due to small vessel disease (SVD). The authors report evidence that ACE gene DD homozygosity of the I/D polymorphism in intron 16 is an independent risk factor for SIH, and not for SVD stroke, in a Polish population.

Received July 30, 2003. Accepted in final form March 5, 2004.




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