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Hashimoto’s encephalopathy

Postmortem findings after fatal status epilepticus

From the Departments of Neurology (Dr. Duffey), Anaesthesiology (Dr. Yee), and Pathology (Dr. Reid), York Hospital, and Department of Neuropathology (Dr. Bridges), Leeds General Infirmary, UK.

Address correspondence and reprint requests to Dr. P. Duffey, Department of Neurology, York Hospital, Wigginton Road, York, YO3 7HE, UK; e-mail: phil.duffey{at}york.nhs.uk

The clinical features of Hashimoto’s encephalopathy have been attributed to a cerebral vasculitis, but pathologic material is rarely available. The authors describe an individual with Hashimoto’s encephalopathy complicated by fatal status epilepticus. Postmortem examination demonstrated mild perivascular lymphocytic infiltration throughout the brain and leptomeninges plus diffuse gliosis of gray matter in the cortex, basal ganglia, thalami, hippocampi, and, to a lesser extent, the parenchymal white matter.

Received February 11, 2003. Accepted in final form May 29, 2003.

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