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NEUROLOGY 2003;61:1607-1610
© 2003 American Academy of Neurology
Brief Communications

Diagnostic value of sural nerve matrix metalloproteinase-9 in diabetic patients with CIDP

S. Jann, MD, M. A. Bramerio, MD, S. Beretta, MD, S. Koch, C. A. Defanti, MD, K. V. Toyka, MD and C. Sommer, MD

From the Departments of Neurology (Drs. Jann and Defanti) and Pathology (Dr. Bramerio), Niguarda Hospital, and Department of Neurology (Dr. Beretta), Vimercate Hospital, Milan, Italy; and Department of Neurology (Drs. Toyka and Sommer, S. Koch), University of Würzburg, Germany.

Address correspondence and reprint requests to Dr. C. Sommer, Neurologische Universitätsklinik, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany; e-mail: sommer{at}mail.uni-wuerzburg.de

Patients with diabetes mellitus (DM) may develop chronic inflammatory demyelinating polyneuropathy (CIDP), which may be difficult to distinguish from diabetic neuropathy (DNP). Here the authors show that immunoreactivity for matrix metalloproteinase-9 on sural nerve biopsies may help to identify CIDP-DM. In a pilot study on 10 CIDP-DM patients with IV immunoglobulins and tight glycemic control, the CIDP-DM patients had a better outcome than DNP patients treated with tight glycemic control only.

Received March 13, 2003. Accepted in final form August 13, 2003.




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