| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
4 in longitudinal cognitive decline
From the Department of Preventive Medicine (P. Bretsky), Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, and Department of Medicine (Dr. Seeman), Division of Geriatrics, University of California at Los Angeles; Laboratory of Epidemiology, Demography, and Biometry (Drs. Guralnik and Launer), National Institute on Aging, NIH, Bethesda, MD; and Department of Psychiatry/Gerontology (Dr. Albert), Massachusetts General Hospital, Harvard Medical School, Boston.
Address correspondence and reprint requests to Philip Bretsky, Department of Preventive Medicine, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, Los Angeles, CA 90033; e-mail: pbretsky{at}usc.edu
Background: While a genetic risk factor for late-onset AD, the effects of the 
4 allele of the APOE gene on cognitive functioning more generally remain unclear.
Objective: To assess the role of the 4 allele of the APOE gene in longitudinal cognitive decline.
Methods: Multiple measures of cognitive function were assessed longitudinally in the MacArthur Successful Aging Study, a population-based cohort free of frank impairment at baseline. Subjects were 965 Caucasian and African American men and women from Durham NC, East Boston, MA, and New Haven, CT, aged 70 to 79 years, recruited in 1988 through 1989, who completed two follow-up evaluations, one at 3 years and another at 7 years.
Results: At the first follow-up, modest but significant declines in naming and spatial ability were associated with the APOE-4 genotype. By the second follow-up, more pronounced and significant associations were noted between the APOE-4 genotype and cognitive decline from six of the eight cognitive outcomes. After 7 years, APOE-4 allele carriers were twice as likely to have declined on a global cognitive score (odds ratio = 2.0; 95% CI: 1.1, 3.6) as noncarriers.
Conclusions: APOE-4 is associated with cognitive decline among a high-functioning elderly cohort, with effects most pronounced after 7 years of follow-up. Hence, the 4 allele either may function as a risk factor for cognitive impairment in normal aging across a broad spectrum of domains or may exert detectable effects early in a long prodromal AD trajectory.
This article has been cited by other articles:
|
|
 |
|
  F Zhang, M Lewis, G Yang, J Iriondo-Perez, Y Zeng, and J Liu Apolipoprotein E polymorphism, life stress and self-reported health among older adults J Epidemiol Community Health, April 1, 2008; 62(4): e3 - e3. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Rosnick, B. J. Small, C. L. McEvoy, A. R. Borenstein, and J. A. Mortimer Negative Life Events and Cognitive Performance in a Population of Older Adults J Aging Health, August 1, 2007; 19(4): 612 - 629. [Abstract] [PDF]
|
|
|
|
 |
|
 C. M. de Frias, D. Bunce, A. Wahlin, R. Adolfsson, K. Sleegers, M. Cruts, C. Van Broeckhoven, and L.-G. Nilsson Cholesterol and Triglycerides Moderate the Effect of Apolipoprotein E on Memory Functioning in Older Adults J. Gerontol. B. Psychol. Sci. Soc. Sci., March 1, 2007; 62(2): P112 - P118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Dunn, S. Weintraub, A. M. Stoddard, and S. Banks Serum {alpha}-tocopherol, concurrent and past vitamin E intake, and mild cognitive impairment Neurology, February 27, 2007; 68(9): 670 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Kuroda, M. E. Weck, J. F. Sarwark, A. Hamidullah, and M. S. Wainwright Association of Apolipoprotein E Genotype and Cerebral Palsy in Children Pediatrics, February 1, 2007; 119(2): 306 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Wishart, A. J. Saykin, T. W. McAllister, L. A. Rabin, B. C. McDonald, L. A. Flashman, R. M. Roth, A. C. Mamourian, G. J. Tsongalis, and C. H. Rhodes Regional brain atrophy in cognitively intact adults with a single APOE {varepsilon}4 allele. Neurology, October 10, 2006; 67(7): 1221 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Burgos, C. Ramirez, I. Sastre, and F. Valdivieso Effect of apolipoprotein e on the cerebral load of latent herpes simplex virus type 1 DNA. J. Virol., June 1, 2006; 80(11): 5383 - 5387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hu, P. Bretsky, E. M. Crimmins, J. M. Guralnik, D. B. Reuben, and T. E. Seeman Association Between Serum Beta-Carotene Levels and Decline of Cognitive Function in High-Functioning Older Persons With or Without Apolipoprotein E 4 Alleles: MacArthur Studies of Successful Aging. J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2006; 61(6): 616 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Lam, N. L. Tang, S. Ma, V. W. Lui, A. S. Chan, P Y Leung, and H. F. Chiu Apolipoprotein epsilon-4 allele and the two-year progression of cognitive function in Chinese subjects with late-onset Alzheimer's disease American Journal of Alzheimer's Disease and Other Dementias, March 1, 2006; 21(2): 92 - 99. [Abstract] [PDF]
|
|
|
|
|
|
E. J. Heyer, D. A. Wilson, D. H. Sahlein, J. Mocco, S. C. Williams, R. Sciacca, A. Rampersad, R. J. Komotar, J. Zurica, A. Benvenisty, et al. APOE-{varepsilon}4 predisposes to cognitive dysfunction following uncomplicated carotid endarterectomy Neurology, December 13, 2005; 65(11): 1759 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Swan, C. N. Lessov-Schlaggar, D. Carmelli, G. D. Schellenberg, and A. La Rue Apolipoprotein E {epsilon}4 and Change in Cognitive Functioning in Community-Dwelling Older Adults J Geriatr Psychiatry Neurol, December 1, 2005; 18(4): 196 - 201. [Abstract] [PDF]
|
|
|
|
 |
|
 G. D. Kolovou, K. K. Anagnostopoulou, D. P. Mikhailidis, D. B. Panagiotakos, N. D. Pilatis, M. A. Cariolou, N. Yiannakouris, D. Degiannis, G. Stavridis, and D. V. Cokkinos Association of Apolipoprotein E Genotype with Early Onset of Coronary Heart Disease in Greek Men Angiology, November 1, 2005; 56(6): 663 - 670. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Rowan, C.M. Morris, S. Stephens, C. Ballard, H. Dickinson, H. Rao, B.K. Saxby, A.T. McLaren, R.N. Kalaria, and R.A. Kenny Impact of Hypertension and Apolipoprotein E4 on Poststroke Cognition in Subjects >75 Years of Age Stroke, September 1, 2005; 36(9): 1864 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Moody-Ayers, K. M. Mehta, K. Lindquist, L. Sands, and K. E. Covinsky Black-White Disparities in Functional Decline in Older Persons: The Role of Cognitive Function J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2005; 60(7): 933 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Devanand, G. H. Pelton, D. Zamora, X. Liu, M. H. Tabert, M. Goodkind, N. Scarmeas, I. Braun, Y. Stern, and R. Mayeux Predictive Utility of Apolipoprotein E Genotype for Alzheimer Disease in Outpatients With Mild Cognitive Impairment Arch Neurol, June 1, 2005; 62(6): 975 - 980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bunce, M. Kivipelto, and A. Wahlin Apolipoprotein E, B Vitamins, and Cognitive Function in Older Adults J. Gerontol. B. Psychol. Sci. Soc. Sci., May 1, 2005; 60(1): P41 - P48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Wayne, B. J. Vellas, S. G. Brodie, P. J. Garry, and R. N. Baumgartner Apolipoprotein {varepsilon}4 Allele and Problems With Orientation Are Associated With a Persistent Decline in Cognition in Community-Dwelling Elderly Persons J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2005; 60(3): 375 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Seeman, M.-H. Huang, P. Bretsky, E. Crimmins, L. Launer, and J. M. Guralnik Education and APOE-e4 in Longitudinal Cognitive Decline: MacArthur Studies of Successful Aging J. Gerontol. B. Psychol. Sci. Soc. Sci., March 1, 2005; 60(2): P74 - P83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Blair, A. R. Folsom, D. S. Knopman, M. S. Bray, T. H. Mosley, E. Boerwinkle, and for the Atherosclerosis Risk in Communities Study APOE genotype and cognitive decline in a middle-aged cohort Neurology, January 25, 2005; 64(2): 268 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Bond, R. Burr, S. M. Mccurry, M. M. Rice, A. R. Borenstein, W. A. Kukull, L. Teri, J. D. Bowen, W. C. Mccormick, and E. B. Larson Alcohol, Gender, and Cognitive Performance: A Longitudinal Study Comparing Older Japanese and Non-Hispanic White Americans J Aging Health, November 1, 2004; 16(5): 615 - 640. [Abstract] [PDF]
|
|
|
|
|
|
C. G. Ballard, C. M. Morris, H. Rao, J. T. O'Brien, R. Barber, S. Stephens, E. Rowan, A. Gibson, R. N. Kalaria, and R. A. Kenny APOE {epsilon}4 and cognitive decline in older stroke patients with early cognitive impairment Neurology, October 26, 2004; 63(8): 1399 - 1402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Weuve, J. H. Kang, J. E. Manson, M. M. B. Breteler, J. H. Ware, and F. Grodstein Physical Activity, Including Walking, and Cognitive Function in Older Women JAMA, September 22, 2004; 292(12): 1454 - 1461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bunce, L. Fratiglioni, B. J. Small, B. Winblad, and L. Backman APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging Neurology, September 14, 2004; 63(5): 816 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sundstrom, P. Marklund, L. -G. Nilsson, M. Cruts, R. Adolfsson, C. Van Broeckhoven, and L. Nyberg APOE influences on neuropsychological function after mild head injury: Within-person comparisons Neurology, June 8, 2004; 62(11): 1963 - 1966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. F. Tannock, T. A. Ahles, P. A. Ganz, and F. S. van Dam Cognitive Impairment Associated With Chemotherapy for Cancer: Report of a Workshop J. Clin. Oncol., June 1, 2004; 22(11): 2233 - 2239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Raz, K. M. Rodrigue, D. Head, K. M. Kennedy, and J. D. Acker Differential aging of the medial temporal lobe: A study of a five-year change Neurology, February 10, 2004; 62(3): 433 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Greenwood and R. Parasuraman Normal Genetic Variation, Cognition, and Aging Behav Cogn Neurosci Rev, December 1, 2003; 2(4): 278 - 306. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
