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Neurology 2002;59:1272-1274
© 2002 American Academy of Neurology
Brief Communications

Ultradian sleep-cycle variation of serotonin in the human lateral ventricle

J. M. Zeitzer, PhD, N. T. Maidment, PhD, E. J. Behnke, BS, L. C. Ackerson, BS, I. Fried, MD PhD, J. Engel, Jr., MD PhD and C. L. Wilson, PhD

From the Departments of Neurology (Drs. Zeitzer, Engel, and Wilson, E.J. Behnke), Psychiatry and Biobehavioral Sciences (Dr. Maidment and L.C. Ackerson), and Neurobiology (Dr. Engel); Brain Research Institute (Drs. Zeitzer, Maidment, Fried, Engel, and Wilson); Neuropsychiatric Institute (Drs. Maidment and Fried); and Division of Neurosurgery (Dr. Fried and E.J. Behnke); David Geffen School of Medicine, University of California, Los Angeles.

Address correspondence and reprint requests to Dr. C.L. Wilson, Department of Neurology, 2155 RNRC, 710 Westwood Plaza, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095; e-mail: clwilson{at}ucla.edu

Serotonin is thought to be intimately involved in the regulation of sleep and waking in humans, though the evidence for such is indirect. Using in vivo microdialysis, the authors show that serotonin in human ventricular CSF covaries with the state of consciousness. They hypothesize that CSF serotonin may be acting in an endocrine-like manner through activation of known leptomeningeal serotonin receptors and possibly participating in modulation of choroidal production of CSF.