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Neurology 2002;59:914-916
© 2002 American Academy of Neurology
Historical Neurology

Denny–Brown, Wilson’s disease, and BAL (British antilewisite [2,3-dimercaptopropanol])

Joel A. Vilensky, PhD, Wendy M. Robertson, MD and Sid Gilman, MD

From the Department of Anatomy and Cell Biology (Dr. Vilensky), Indiana University School of Medicine, Fort Wayne, IN; Ann Arbor Neurological Associates (Dr. Robertson), Ann Arbor; and Department of Neurology (Dr. Gilman), University of Michigan School of Medicine, Ann Arbor, MI.

Address correspondence and reprint requests to Dr. Joel A. Vilensky, Indiana University School of Medicine, 2101 Coliseum Blvd. East, Fort Wayne, IN 46805; e-mail: vilensk{at}ipfw.edu

In 1951 Denny–Brown and Porter described the successful treatment of Wilson’s disease using the chelating agent British antilewisite. The presentation of their results both at meetings and in print changed the traditional view of neurology from a descriptive to an interventional discipline using treatments based on the underlying biochemical disorder. The authors review the importance of these reports and provide edited digital versions of the films Denny–Brown made of the five patients described in the initial reports.




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