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 Volume 59, Number 1, July 09, 2002
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Neurology 2002;59:121-123
© 2002 American Academy of Neurology
Brief Communications

Radiotherapy-induced cerebral abnormalities in patients with low-grade glioma

T. J. Postma, MD, M. Klein, PhD, C. C.P. Verstappen, MD, J. E.C. Bromberg, MD, M. Swennen, MD, J. A. Langendijk, MD, M. J.B. Taphoorn, MD, P. Scheltens, MD, B. J. Slotman, MD, H. M. van der Ploeg, PhD, N. K. Aaronson, PhD and J. J. Heimans, MD

From the Departments of Neurology (Drs. Postma, Verstappen, Scheltens, and Heimans), Medical Psychology (Drs. Klein, van der Ploeg, and Aaronson), and Radiation Oncology (Drs. Langendijk and Slotman), Vrije Universiteit Medical Center, Amsterdam; Department of Neurology (Drs. Bromberg, Swennen, and Taphoorn), University Medical Center, Utrecht; Department of Psychosocial Research and Epidemiology (Dr. Aaronson), The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Address correspondence and reprint requests to T.J. Postma, MD, Dept. of Neurology, Vrije Universiteit Medical Center, P.O. Box 7057, 1007 MB Amsterdam, the Netherlands; e-mail: TJ.Postma{at}vumc.nl

Abnormalities on CT or MRI and neuropsychological performance in patients with low-grade glioma, with (n = 23) or without (n = 16) prior cerebral radiotherapy, were evaluated. Cerebral atrophy was observed in 14 of 23 patients (61%) treated with prior radiotherapy, and in 1 of 16 patients (6%) without prior radiotherapy. White matter abnormalities were observed in six patients, all of whom were treated with prior radiotherapy. These radiologic cerebral abnormalities correlated with cognitive performance.




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