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Multiple sclerosis–associated retrovirus (MSRV) in Sardinian MS patients

From the Section of Experimental and Clinical Microbiology, Department of Biomedical Sciences (Drs. Dolei and Serra, and G. Mameli), University of Sassari, Viale San Pietro 43/B, I-07100 Sassari; Institute of Clinical Neurology (Drs. Pugliatti, Sechi, Rosati, and Sotgiu), University of Sassari, Viale San Pietro; and Immunohematology Unit (M.C. Cirotto), ASL n. 1 Transfusion Center, Sassari, Italy.

Address correspondence and reprint requests to Prof. A. Dolei, Section of Experimental and Clinical Microbiology, Department of Biomedical Sciences, Viale San Pietro 43/B, I-07100, Sassari, Italy; e-mail: doleivir{at}ssmain.uniss.it

Blood and CSF of Sardinian patients with MS and neurologic control subjects were tested for MS-associated retrovirus (MSRV). CSF detection in MS was 50% at clinical onset, increasing with temporal disease progression, and 40% in control subjects. In blood, MSRV was detected in all MS patients, in most patients with inflammatory neurologic diseases, and rarely in healthy blood donors. MSRV may represent a marker of neurologic diseases of inflammatory origin.