Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Casanova, M. F.
Right arrow Articles by Roy, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Casanova, M. F.
Right arrow Articles by Roy, E.
Neurology 2002;58:428-432
© 2002 American Academy of Neurology

Minicolumnar pathology in autism

Manuel F. Casanova, MD, Daniel P. Buxhoeveden, PhD, Andrew E. Switala and Emil Roy, PhD

From Medical College of Georgia (Dr. Casanova), Augusta; Department of Anthropology (Dr. Buxhoeveden), University of South Carolina, Columbia; and Downtown Veterans Administration Medical Center (Drs. Casanova and Roy, and A. Switala), Augusta, GA.

Address correspondence and reprint requests to Dr. Manuel F. Casanova, Downtown VA Medical Center, 26 Psychiatry Service, 3B-121, Augusta, GA 30910; e-mail: casanova{at}np2.mcg.edu

Objective: To determine whether differences exist in the configuration of minicolumns between the brains of autistic and control patients.

Background: Autism is a severe and pervasive developmental disturbance of childhood characterized by disturbances in both social interactions and communication, as well as stereotyped patterns of interests, activities, and behaviors. Postmortem neuropathologic studies remain inconclusive.

Methods: The authors used a computerized imaging program to measure details of cell column morphologic features in area 9 of the prefrontal cortex and areas 21 and posterior 22 (Tpt) within the temporal lobe of nine brains of autistic patients and controls.

Results: The authors found significant differences between brains of autistic patients and controls in the number of minicolumns, in the horizontal spacing that separates cell columns, and in their internal structure, that is, relative dispersion of cells. Specifically, cell columns in brains of autistic patients were more numerous, smaller, and less compact in their cellular configuration with reduced neuropil space in the periphery.

Conclusions: In autism, there are minicolumnar abnormalities in the frontal and temporal lobes of the brain.




This article has been cited by other articles:


Home page
 Cereb CortexHome page
S. K. Sundaram, A. Kumar, M. I. Makki, M. E. Behen, H. T. Chugani, and D. C. Chugani
Diffusion Tensor Imaging of Frontal Lobe in Autism Spectrum Disorder
Cereb Cortex, November 1, 2008; 18(11): 2659 - 2665.
[Abstract] [Full Text] [PDF]

Home page
 FocusHome page
A. Westphal and F. R. Volkmar
An Update on Autism
Focus, June 1, 2008; 6(3): 284 - 292.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
T. Rinaldi, G. Silberberg, and H. Markram
Hyperconnectivity of Local Neocortical Microcircuitry Induced by Prenatal Exposure to Valproic Acid
Cereb Cortex, April 1, 2008; 18(4): 763 - 770.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. W. G. Vandenbroucke, H. S. Scholte, H. van Engeland, V. A. F. Lamme, and C. Kemner
A neural substrate for atypical low-level visual processing in autism spectrum disorder
Brain, April 1, 2008; 131(4): 1013 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
B. Manzi, A. L. Loizzo, G. Giana, and P. Curatolo
Autism and Metabolic Diseases
J Child Neurol, March 1, 2008; 23(3): 307 - 314.
[Abstract] [PDF]

Home page
 NeuroscientistHome page
M. F. Casanova and C. R. Tillquist
Encephalization, Emergent Properties, and Psychiatry: A Minicolumnar Perspective
Neuroscientist, February 1, 2008; 14(1): 101 - 118.
[Abstract] [PDF]

Home page
 AutismHome page
M. F. Casanova, A. E. Switala, J. Trippe, and M. Fitzgerald
Comparative minicolumnar morphometry of three distinguished scientists
Autism, November 1, 2007; 11(6): 557 - 569.
[Abstract] [PDF]

Home page
 PediatricsHome page
C. P. Johnson, S. M. Myers, and and the Council on Children With Disabilities
Identification and Evaluation of Children With Autism Spectrum Disorders
Pediatrics, November 1, 2007; 120(5): 1183 - 1215.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Kenet, R. C. Froemke, C. E. Schreiner, I. N. Pessah, and M. M. Merzenich
Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex
PNAS, May 1, 2007; 104(18): 7646 - 7651.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Loddo, S. R. Dager, H. Petropoulos, S. D. Friedman, and D. W.W. Shaw
Gray matter abnormalities in autism spectrum disorder revealed by T2 relaxation
Neurology, April 10, 2007; 68(15): 1237 - 1238.
[Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
T. A. Williams, A. E. Mars, S. G. Buyske, E. S. Stenroos, R. Wang, M. F. Factura-Santiago, G. H. Lambert, and W. G. Johnson
Risk of Autistic Disorder in Affected Offspring of Mothers With a Glutathione S-Transferase P1 Haplotype
Arch Pediatr Adolesc Med, April 1, 2007; 161(4): 356 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. A. Just, V. L. Cherkassky, T. A. Keller, R. K. Kana, and N. J. Minshew
Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum Morphometry
Cereb Cortex, April 1, 2007; 17(4): 951 - 961.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
M. F. Casanova
Neuropathological and Genetic Findings in Autism: The Significance of a Putative Minicolumnopathy
Neuroscientist, October 1, 2006; 12(5): 435 - 441.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
N. Hadjikhani, R. M. Joseph, J. Snyder, and H. Tager-Flusberg
Anatomical Differences in the Mirror Neuron System and Social Cognition Network in Autism
Cereb Cortex, September 1, 2006; 16(9): 1276 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Petropoulos, S. D. Friedman, D.W.W. Shaw, A. A. Artru, G. Dawson, and S. R. Dager
Gray matter abnormalities in autism spectrum disorder revealed by T2 relaxation.
Neurology, August 22, 2006; 67(4): 632 - 636.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
B. Korkmaz, G. Benbir, and V. Demirbilek
Migration Abnormality in the Left Cingulate Gyrus Presenting With Autistic Disorder
J Child Neurol, July 1, 2006; 21(7): 600 - 604.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
E. DiCicco-Bloom, C. Lord, L. Zwaigenbaum, E. Courchesne, S. R. Dager, C. Schmitz, R. T. Schultz, J. Crawley, and L. J. Young
The developmental neurobiology of autism spectrum disorder.
J. Neurosci., June 28, 2006; 26(26): 6897 - 6906.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
A. S. Chan and W. W. M. Leung
Differentiating Autistic Children with Quantitative Encephalography: A 3-Month Longitudinal Study
J Child Neurol, May 1, 2006; 21(5): 391 - 399.
[Abstract] [PDF]

Home page
 AutismHome page
M. Liss, C. Saulnier, D. Fein, and M. Kinsbourne
Sensory and attention abnormalities in autistic spectrum disorders.
Autism, March 1, 2006; 10(2): 155 - 172.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
T. Antonelli, M. C. Tomasini, M. Tattoli, T. Cassano, S. Tanganelli, S. Finetti, E. Mazzoni, L. Trabace, L. Steardo, V. Cuomo, et al.
Prenatal Exposure to the CB1 Receptor Agonist WIN 55,212-2 Causes Learning Disruption Associated with Impaired Cortical NMDA Receptor Function and Emotional Reactivity Changes in Rat Offspring
Cereb Cortex, December 1, 2005; 15(12): 2013 - 2020.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
S. L. Connors, D. E. Crowell, C. G. Eberhart, J. Copeland, C. J. Newschaffer, S. J. Spence, and A. W. Zimmerman
{beta} 2-Adrenergic Receptor Activation and Genetic Polymorphisms in Autism: Data from Dizygotic Twins
J Child Neurol, November 1, 2005; 20(11): 876 - 884.
[Abstract] [PDF]

Home page
 NeuroscientistHome page
M. R. Herbert
Large Brains in Autism: The Challenge of Pervasive Abnormality
Neuroscientist, October 1, 2005; 11(5): 417 - 440.
[Abstract] [PDF]

Home page
 BrainHome page
A. Bertone, L. Mottron, P. Jelenic, and J. Faubert
Enhanced and diminished visuo-spatial information processing in autism depends on stimulus complexity
Brain, October 1, 2005; 128(10): 2430 - 2441.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. Limoges, L. Mottron, C. Bolduc, C. Berthiaume, and R. Godbout
Atypical sleep architecture and the autism phenotype
Brain, May 1, 2005; 128(5): 1049 - 1061.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. J. M. C. Palmen, H. van Engeland, P. R. Hof, and C. Schmitz
Neuropathological findings in autism
Brain, December 1, 2004; 127(12): 2572 - 2583.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
Y. Takarae, N. J. Minshew, B. Luna, C. M. Krisky, and J. A. Sweeney
Pursuit eye movement deficits in autism
Brain, December 1, 2004; 127(12): 2584 - 2594.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Cruz, D. L. Roe, B. Urbanc, H. Cabral, H. E. Stanley, and D. L. Rosene
Age-related reduction in microcolumnar structure in area 46 of the rhesus monkey correlates with behavioral decline
PNAS, November 9, 2004; 101(45): 15846 - 15851.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. K. Belmonte, G. Allen, A. Beckel-Mitchener, L. M. Boulanger, R. A. Carper, and S. J. Webb
Autism and Abnormal Development of Brain Connectivity
J. Neurosci., October 20, 2004; 24(42): 9228 - 9231.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
M. R. Herbert
Neuroimaging in Disorders of Social and Emotional Functioning: What Is the Question?
J Child Neurol, October 1, 2004; 19(10): 772 - 784.
[Abstract] [PDF]

Home page
 Cereb CortexHome page
S. M. Mooney, J. A. Siegenthaler, and M. W. Miller
Ethanol Induces Heterotopias in Organotypic Cultures of Rat Cerebral Cortex
Cereb Cortex, October 1, 2004; 14(10): 1071 - 1080.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. A. Just, V. L. Cherkassky, T. A. Keller, and N. J. Minshew
Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity
Brain, August 1, 2004; 127(8): 1811 - 1821.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
S Baron-Cohen
The cognitive neuroscience of autism
J. Neurol. Neurosurg. Psychiatry, July 1, 2004; 75(7): 945 - 948.
[Full Text] [PDF]

Home page
 NeuroscientistHome page
L. Gustafsson
Comment on "Disruption in the Inhibitory Architecture of the Cell Minicolumn: Implications for Autism"
Neuroscientist, June 1, 2004; 10(3): 189 - 191.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
L. J. Lotspeich, H. Kwon, C. M. Schumann, S. L. Fryer, B. L. Goodlin-Jones, M. H. Buonocore, C. R. Lammers, D. G. Amaral, and A. L. Reiss
Investigation of Neuroanatomical Differences Between Autism and Asperger Syndrome
Arch Gen Psychiatry, March 1, 2004; 61(3): 291 - 298.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Janusonis, V. Gluncic, and P. Rakic
Early Serotonergic Projections to Cajal-Retzius Cells: Relevance for Cortical Development
J. Neurosci., February 18, 2004; 24(7): 1652 - 1659.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
M. F. Casanova, D. Buxhoeveden, and J. Gomez
Disruption in the Inhibitory Architecture of the Cell Minicolumn: Implications for Autisim
Neuroscientist, December 1, 2003; 9(6): 496 - 507.
[Abstract] [PDF]

Home page
 BrainHome page
J. M. Foxton, M. E. Stewart, L. Barnard, J. Rodgers, A. H. Young, G. O'Brien, and T. D. Griffiths
Absence of auditory 'global interference' in autism
Brain, December 1, 2003; 126(12): 2703 - 2709.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. D. Bigler, D. F. Tate, E. S. Neeley, L. J. Wolfson, M. J. Miller, S. A. Rice, H. Cleavinger, C. Anderson, H. Coon, S. Ozonoff, et al.
Temporal Lobe, Autism, and Macrocephaly
AJNR Am. J. Neuroradiol., November 1, 2003; 24(10): 2066 - 2076.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
R.-A. Muller, N. Kleinhans, N. Kemmotsu, K. Pierce, and E. Courchesne
Abnormal Variability and Distribution of Functional Maps in Autism: An fMRI Study of Visuomotor Learning
Am J Psychiatry, October 1, 2003; 160(10): 1847 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
E. Courchesne, R. Carper, and N. Akshoomoff
Evidence of Brain Overgrowth in the First Year of Life in Autism
JAMA, July 16, 2003; 290(3): 337 - 344.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. E. Lainhart
Increased Rate of Head Growth During Infancy in Autism
JAMA, July 16, 2003; 290(3): 393 - 394.
[Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. S. B. C. Ang Jr, T. F. Haydar, V. Gluncic, and P. Rakic
Four-Dimensional Migratory Coordinates of GABAergic Interneurons in the Developing Mouse Cortex
J. Neurosci., July 2, 2003; 23(13): 5805 - 5815.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. R. Herbert, D. A. Ziegler, C. K. Deutsch, L. M. O'Brien, N. Lange, A. Bakardjiev, J. Hodgson, K. T. Adrien, S. Steele, N. Makris, et al.
Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys
Brain, May 1, 2003; 126(5): 1182 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
P. Szatmari
The causes of autism spectrum disorders
BMJ, January 25, 2003; 326(7382): 173 - 174.
[Full Text] [PDF]

Home page
 NeurologyHome page
S.D. Friedman, D.W. Shaw, A.A. Artru, T.L. Richards, J. Gardner, G. Dawson, S. Posse, and S.R. Dager
Regional brain chemical alterations in young children with autism spectrum disorder
Neurology, January 14, 2003; 60(1): 100 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
M. F. Casanova, D. P. Buxhoeveden, and C. Brown
Clinical and Macroscopic Correlates of Minicolumnar Pathology in Autism
J Child Neurol, September 1, 2002; 17(9): 692 - 695.
[Abstract] [PDF]

Home page
 BrainHome page
D. P. Buxhoeveden and M. F. Casanova
The minicolumn hypothesis in neuroscience
Brain, May 1, 2002; 125(5): 935 - 951.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by AAN Enterprises, Inc.