Neurology 2002;58:422-427
© 2002 American Academy of Neurology
Migraine and autonomic nervous system function
A population-based, case-control study
Aaron Shechter, BA,
Walter F. Stewart, PhD MPH;,
Stephen D. Silberstein, MD and
Richard B. Lipton, MD
From the Department of Epidemiology (Dr. Stewart and A. Shechter), the Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; Jefferson Headache Center (Dr. Silberstein and A. Shecter), Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA; Department of Neurology, Epidemiology, and Social Medicine (Drs. Stewart and Lipton), Albert Einstein College of Medicine and Headache Unit, Montefiore Medical Center, Bronx, NY; and Innovative Medical Research (Dr. Lipton), Towson, MD, and Stamford, CT.
Address correspondence and reprint requests to A. Shechter, Jefferson Headache Center, Department of Neurology, Thomas Jefferson University Hospital, 111 S. 11th Street, Suite 8130, Philadelphia, PA 19107; e-mail: ashechter{at}hotmail.com
Objective: This study determines if measures of the function of the autonomic nervous system (ANS) differ in a population study of 80 migraine cases vs 85 controls matched for age, race, and sex.
Background: The authors sought to confirm clinic-based studies suggesting that migraine is associated with abnormal ANS function.
Methods: Resting systolic and diastolic blood pressure, Valsalva maneuver, heart rate variability (pulse rate [RR] variation) during deep breathing, and cardiovascular reactivity were measured during headache-free intervals. Migraineurs were subdivided into those with (n = 28) and without (n = 52) disabling headaches.
Results: Resting diastolic, but not systolic, blood pressure was elevated in disabled (73.2 mm) compared with nondisabled cases (71.6 mm; p < 0.10) and controls (69.8 mm; p < 0.096). RR variation also was significantly different among the three groups. Disabled migraine cases (1.19) had significantly lower RR variation compared with nondisabled migraine cases (1.26; p < 0.001) and controls (1.26; p < 0.001). The Valsalva ratio and mean circular resultant were lower in disabled cases compared with other migraine cases and with controls, but the differences were not statistically significant. No differences were found between the three groups when comparing blood pressure response to a psychological stressor.
Conclusions: Migraineurs with disabling attacks may be prone to ANS hypofunction. These findings may suggest that ANS dysfunction either may be a risk factor for migraine headaches or be a consequence of frequent disabling attacks. Moreover, ANS dysfunction and migraine may share a common neural substrate.
This article has been cited by other articles:
|
|
|
|
 
M. Kruit, M. van Buchem, L. Launer, G. Terwindt, and M. Ferrari
Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: The population-based MRI CAMERA study
Cephalalgia,
February 1, 2010;
30(2):
129 - 136.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Benditt and J. T. Nguyen
Syncope: therapeutic approaches.
J. Am. Coll. Cardiol.,
May 12, 2009;
53(19):
1741 - 1751.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Schwaiger, S. Kiechl, H. Stockner, M. Knoflach, P. Werner, G. Rungger, A. Gasperi, and J. Willeit
Burden of atherosclerosis and risk of venous thromboembolism in patients with migraine
Neurology,
September 16, 2008;
71(12):
937 - 943.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Aamodt, L. Stovner, K Hagen, and J-A Zwart
Comorbidity of Headache and Gastrointestinal Complaints. The Head-HUNT Study
Cephalalgia,
February 1, 2008;
28(2):
144 - 151.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Brenner, D. S. Summers, and J. N. de Hoon
ALTERED ARTERIAL FUNCTION IN MIGRAINE OF RECENT ONSET
Neurology,
November 20, 2007;
69(21):
2028 - 2029.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Oterino, C Ruiz-Alegria, J Castillo, N Valle, Y Bravo, A Cayon, A Alonso, P Tejera, N Ruiz-Lavilla, P Munoz, et al.
GNAS1 T393C Polymorphism is Associated With Migraine
Cephalalgia,
May 1, 2007;
27(5):
429 - 434.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R Virtanen, M Aromaa, P Rautava, L Metsahonkala, P Anttila, H Helenius, and M Sillanpaa
Changing Headache from Preschool Age to Puberty. A Controlled Study
Cephalalgia,
April 1, 2007;
27(4):
294 - 303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Blitshteyn, W. P. Cheshire Jr, I. T. Jarjour, E. O. Smith, R .D. Thijs, M .C. Kruit, M .A. van Buchem, M .D. Ferrari, L .J. Launer, and J .G. van Dijk
Syncope in migraine: the population-based CAMERA study.
Neurology,
March 13, 2007;
68(11):
878 - 878.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R Gupta and M. Bhatia
A Report of Cranial Autonomic Symptoms in Migraineurs
Cephalalgia,
January 1, 2007;
27(1):
22 - 28.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Duru, I Melek, E Seyfeli, T Duman, G Kuvandik, H Kaya, and F Yalcm
QTC Dispersion and P-Wave Dispersion during Migraine Attacks
Cephalalgia,
June 1, 2006;
26(6):
672 - 677.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Thijs, M. C. Kruit, M. A. van Buchem, M. D. Ferrari, L. J. Launer, and J. G. van Dijk
Syncope in migraine: The population-based CAMERA study
Neurology,
April 11, 2006;
66(7):
1034 - 1037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F Ebinger, M Kruse, U Just, and D Rating
Cardiorespiratory Regulation in Migraine. Results in Children and Adolescents and Review of the Literature
Cephalalgia,
March 1, 2006;
26(3):
295 - 309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. I. Scher, G. M. Terwindt, H. S.J. Picavet, W. M.M. Verschuren, M. D. Ferrari, and L. J. Launer
Cardiovascular risk factors and migraine: The GEM population-based study
Neurology,
February 22, 2005;
64(4):
614 - 620.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Avnon, M. Nitzan, E. Sprecher, Z. Rogowski, and D. Yarnitsky
Autonomic asymmetry in migraine: augmented parasympathetic activation in left unilateral migraineurs
Brain,
September 1, 2004;
127(9):
2099 - 2108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. De Marinis
Migraine and autonomic nervous system function: A population-based, case-control study
Neurology,
August 12, 2003;
61(3):
424 - 425.
[Full Text]
[PDF]
|
|
|
Correspondence:
Read all Correspondence
- Migraine and autonomic nervous system function: A population-based, case-control study
- Milena De Marinis
- Neurology Online, 25 Feb 2003
[Full text]
|
