Neurology 2002;58:198-208
© 2002 American Academy of Neurology
Patterns of brain atrophy in frontotemporal dementia and semantic dementia
H. J. Rosen, MD,
M. L. Gorno–Tempini, MD,
W. P. Goldman, PhD,
R. J. Perry, MD,
N. Schuff, PhD,
M. Weiner, MD,
R. Feiwell, MD,
J. H. Kramer, PsyD and
B. L. Miller, MD
From the University of California at San Francisco Department of Neurology (Drs. Rosen, Gorno–Tempini, Goldman, Perry, Weiner, Kramer, and Miller), UCSF Memory and Aging Center (Drs. Rosen, Gorno–Tempini, Goldman, Perry, Kramer, and Miller), San Francisco Veterans Affairs Hospital Magnetic Resonance Spectroscopy Unit (Drs. Schuff and Weiner), University of California at San Francisco Department of Radiology (Drs. Schuff, Weiner, and Feiwell), CA.
Address correspondence and reprint requests to Dr. Howard Rosen, UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave., Suite 800, Box 1207, San Francisco, CA 94143-1207; e-mail: Howie{at}itsa.ucsf.edu
Objective: To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD).
Methods: Twenty patients with FTLD were classified as having FTD (N = 8) or SemD (N = 12) based on current clinical criteria. Both groups showed a similar spectrum of behavioral abnormalities, as indicated by the neuropsychiatric inventory. T1-weighted MRI was obtained for each patient and 20 control subjects. The regions of focal gray matter tissue loss associated with both FTD and SemD, as well as those differing between the two groups were examined using voxel-based morphometry.
Results: Regions of significant atrophy seen in both groups were located in the ventromedial frontal cortex, the posterior orbital frontal regions bilaterally, the insula bilaterally, and the left anterior cingulate cortex. The FTD, but not the SemD, group showed atrophy in the right dorsolateral frontal cortex and the left premotor cortex. The SemD, but not the FTD, group showed tissue loss in the anterior temporal cortex and the amygdala/anterior hippocampal region bilaterally.
Conclusions: Although FTD and SemD are associated with different overall patterns of brain atrophy, regions of gray matter tissue loss in the orbital frontal, insular, and anterior cingulate regions are present in both groups. The authors suggest that pathology in the areas of atrophy associated with both FTD and SemD may underlie some the behavioral symptoms seen in the two disorders.
This article has been cited by other articles:
|
|
|
|
 
M. Hornberger, O. Piguet, A. J. Graham, P. J. Nestor, and J. R. Hodges
How preserved is episodic memory in behavioral variant frontotemporal dementia?
Neurology,
February 9, 2010;
74(6):
472 - 479.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. D. Rabinovici, A. J. Furst, A. Alkalay, C. A. Racine, J. P. O'Neil, M. Janabi, S. L. Baker, N. Agarwal, S. J. Bonasera, E. C. Mormino, et al.
Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden
Brain,
February 1, 2010;
133(2):
512 - 528.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Deramecourt, F. Lebert, B. Debachy, M. A. Mackowiak-Cordoliani, S. Bombois, O. Kerdraon, L. Buee, C. -A. Maurage, and F. Pasquier
Prediction of pathology in primary progressive language and speech disorders
Neurology,
January 5, 2010;
74(1):
42 - 49.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Agosta, R. G. Henry, R. Migliaccio, J. Neuhaus, B. L. Miller, N. F. Dronkers, S. M. Brambati, M. Filippi, J. M. Ogar, S. M. Wilson, et al.
Language networks in semantic dementia
Brain,
January 1, 2010;
133(1):
286 - 299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Whitwell, S. A. Przybelski, S. D. Weigand, R. J. Ivnik, P. Vemuri, J. L. Gunter, M. L. Senjem, M. M. Shiung, B. F. Boeve, D. S. Knopman, et al.
Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study
Brain,
November 1, 2009;
132(11):
2932 - 2946.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, N. Schuff, A.-T. Du, H. J. Rosen, J. H. Kramer, M. L. Gorno-Tempini, B. L. Miller, and M. W. Weiner
White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
Brain,
September 1, 2009;
132(9):
2579 - 2592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Rascovsky, M. E. Growdon, I. R. Pardo, S. Grossman, and B. L. Miller
'The quicksand of forgetfulness': semantic dementia in One Hundred Years of Solitude
Brain,
September 1, 2009;
132(9):
2609 - 2616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Whitwell
Voxel-Based Morphometry: An Automated Technique for Assessing Structural Changes in the Brain
J. Neurosci.,
August 5, 2009;
29(31):
9661 - 9664.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. E. Krueger, A. C. Bird, M. E. Growdon, J. Y. Jang, B. L. Miller, and J. H. Kramer
Conflict monitoring in early frontotemporal dementia
Neurology,
August 4, 2009;
73(5):
349 - 355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Cruchaga, M. A. Fernandez-Seara, M. Seijo-Martinez, L. Samaranch, E. Lorenzo, A. Hinrichs, J. Irigoyen, C. Maestro, E. Prieto, J. M. Marti-Climent, et al.
Cortical Atrophy and Language Network Reorganization Associated with a Novel Progranulin Mutation
Cereb Cortex,
August 1, 2009;
19(8):
1751 - 1760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Knopman, C. R. Jack Jr, J. H. Kramer, B. F. Boeve, R. J. Caselli, N. R. Graff-Radford, M. F. Mendez, B. L. Miller, and N. D. Mercaldo
Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year
Neurology,
May 26, 2009;
72(21):
1843 - 1849.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.M.S. Pereira, G. B. Williams, J. Acosta-Cabronero, G. Pengas, M. G. Spillantini, J. H. Xuereb, J. R. Hodges, and P. J. Nestor
Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
Neurology,
May 12, 2009;
72(19):
1653 - 1660.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Torralva, M. Roca, E. Gleichgerrcht, T. Bekinschtein, and F. Manes
A neuropsychological battery to detect specific executive and social cognitive impairments in early frontotemporal dementia
Brain,
May 1, 2009;
132(5):
1299 - 1309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Zahn, J. Moll, V. Iyengar, E. D. Huey, M. Tierney, F. Krueger, and J. Grafman
Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism
Brain,
March 1, 2009;
132(3):
604 - 616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Agosta, K. A. Vossel, B. L. Miller, R. Migliaccio, S. J. Bonasera, M. Filippi, A. L. Boxer, A. Karydas, K. L. Possin, and M. L. Gorno-Tempini
Apolipoprotein E {varepsilon}4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia
PNAS,
February 10, 2009;
106(6):
2018 - 2022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Wilson, S. M. Brambati, R. G. Henry, D. A. Handwerker, F. Agosta, B. L. Miller, D. P. Wilkins, J. M. Ogar, and M. L. Gorno-Tempini
The neural basis of surface dyslexia in semantic dementia
Brain,
January 1, 2009;
132(1):
71 - 86.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Josephs, J. L. Whitwell, P. Vemuri, M. L. Senjem, B. F. Boeve, D. S. Knopman, G. E. Smith, R. J. Ivnik, R. C. Petersen, and C. R. Jack Jr
The anatomic correlate of prosopagnosia in semantic dementia
Neurology,
November 11, 2008;
71(20):
1628 - 1633.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hornberger, O. Piguet, C. Kipps, and J. R. Hodges
Executive function in progressive and nonprogressive behavioral variant frontotemporal dementia
Neurology,
November 4, 2008;
71(19):
1481 - 1488.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hoefer, S. C. Allison, G. F. Schauer, J. M. Neuhaus, J. Hall, J. N. Dang, M. W. Weiner, B. L. Miller, and H. J. Rosen
Fear conditioning in frontotemporal lobar degeneration and Alzheimer's disease
Brain,
June 1, 2008;
131(6):
1646 - 1657.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Bian, J. C. Van Swieten, S. Leight, L. Massimo, E. Wood, M. Forman, P. Moore, I. de Koning, C. M. Clark, S. Rosso, et al.
CSF biomarkers in frontotemporal lobar degeneration with known pathology
Neurology,
May 6, 2008;
70(19_Part_2):
1827 - 1835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Garbutt, A. Matlin, J. Hellmuth, A. K. Schenk, J. K. Johnson, H. Rosen, D. Dean, J. Kramer, J. Neuhaus, B. L. Miller, et al.
Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease
Brain,
May 1, 2008;
131(5):
1268 - 1281.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. W. Seeley, R. Crawford, K. Rascovsky, J. H. Kramer, M. Weiner, B. L. Miller, and M. L. Gorno-Tempini
Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia
Arch Neurol,
February 1, 2008;
65(2):
249 - 255.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Osher, A. H. Wicklund, A. Rademaker, N. Johnson, and S. Weintraub
The Mini-Mental State Examination in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia
American Journal of Alzheimer's Disease and Other Dementias,
January 1, 2008;
22(6):
468 - 473.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G.D. Rabinovici, W.W. Seeley, E.J. Kim, M.L. Gorno-Tempini, K. Rascovsky, T.A. Pagliaro, S.C. Allison, C. Halabi, J.H. Kramer, J.K. Johnson, et al.
Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration
American Journal of Alzheimer's Disease and Other Dementias,
January 1, 2008;
22(6):
474 - 488.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Spina, M. R. Farlow, F. W. Unverzagt, D. A. Kareken, J. R. Murrell, G. Fraser, F. Epperson, R. A. Crowther, M. G. Spillantini, M. Goedert, et al.
The tauopathy associated with mutation +3 in intron 10 of Tau: characterization of the MSTD family
Brain,
January 1, 2008;
131(1):
72 - 89.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Levy and G. J. Chelune
Cognitive-Behavioral Profiles of Neurodegenerative Dementias: Beyond Alzheimer's Disease
J Geriatr Psychiatry Neurol,
December 1, 2007;
20(4):
227 - 238.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. L. Chao, N. Schuff, E. M. Clevenger, S. G. Mueller, H. J. Rosen, M. L. Gorno-Tempini, J. H. Kramer, B. L. Miller, and M. W. Weiner
Patterns of White Matter Atrophy in Frontotemporal Lobar Degeneration
Arch Neurol,
November 1, 2007;
64(11):
1619 - 1624.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Woolley, M. -L. Gorno-Tempini, W. W. Seeley, K. Rankin, S. S. Lee, B. R. Matthews, and B. L. Miller
Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia
Neurology,
October 2, 2007;
69(14):
1424 - 1433.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. H. Werner, N. A. Roberts, H. J. Rosen, D. L. Dean, J. H. Kramer, M. W. Weiner, B. L. Miller, and R. W. Levenson
Emotional reactivity and emotion recognition in frontotemporal lobar degeneration
Neurology,
July 10, 2007;
69(2):
148 - 155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A. Cardenas, A. L. Boxer, L. L. Chao, M. L. Gorno-Tempini, B. L. Miller, M. W. Weiner, and C. Studholme
Deformation-Based Morphometry Reveals Brain Atrophy in Frontotemporal Dementia
Arch Neurol,
June 1, 2007;
64(6):
873 - 877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. D. Rabinovici, A. J. Furst, J. P. O'Neil, C. A. Racine, E. C. Mormino, S. L. Baker, S. Chetty, P. Patel, T. A. Pagliaro, W. E. Klunk, et al.
11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration
Neurology,
April 10, 2007;
68(15):
1205 - 1212.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Noppeney, K. Patterson, L. K. Tyler, H. Moss, E. A. Stamatakis, P. Bright, C. Mummery, and C. J. Price
Temporal lobe lesions and semantic impairment: a comparison of herpes simplex virus encephalitis and semantic dementia
Brain,
April 1, 2007;
130(4):
1138 - 1147.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.-T. Du, N. Schuff, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. Rankin, B. L. Miller, and M. W. Weiner
Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
Brain,
April 1, 2007;
130(4):
1159 - 1166.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Nishio, H Kazui, M Hashimoto, K Shimizu, K Onouchi, S Mochio, K Suzuki, and E Mori
Actions anchored by concepts: defective action comprehension in semantic dementia
J. Neurol. Neurosurg. Psychiatry,
December 1, 2006;
77(12):
1313 - 1317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Rosen, S. C. Allison, J. M. Ogar, S. Amici, K. Rose, N. Dronkers, B. L. Miller, and M. L. Gorno-Tempini
Behavioral features in semantic dementia vs other forms of progressive aphasias
Neurology,
November 28, 2006;
67(10):
1752 - 1756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A.-L. R. Adlam, K. Patterson, T. T. Rogers, P. J. Nestor, C. H. Salmond, J. Acosta-Cabronero, and J. R. Hodges
Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?
Brain,
November 1, 2006;
129(Pt 11):
3066 - 3080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. R. Davies, C. M. Kipps, J. Mitchell, J. J. Kril, G. M. Halliday, and J. R. Hodges
Progression in Frontotemporal Dementia: Identifying a Benign Behavioral Variant by Magnetic Resonance Imaging
Arch Neurol,
November 1, 2006;
63(11):
1627 - 1631.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Josephs, J. L. Whitwell, C. R. Jack, J. E. Parisi, and D. W. Dickson
Frontotemporal Lobar Degeneration Without Lobar Atrophy
Arch Neurol,
November 1, 2006;
63(11):
1632 - 1638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. P. Rankin, M. L. Gorno-Tempini, S. C. Allison, C. M. Stanley, S. Glenn, M. W. Weiner, and B. L. Miller
Structural anatomy of empathy in neurodegenerative disease
Brain,
November 1, 2006;
129(11):
2945 - 2956.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. T. Du, G. H. Jahng, S. Hayasaka, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. P. Rankin, B. L. Miller, M. W. Weiner, and N. Schuff
Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI.
Neurology,
October 10, 2006;
67(7):
1215 - 1220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Barnes, J. L. Whitwell, C. Frost, K. A. Josephs, M. Rossor, and N. C. Fox
Measurements of the Amygdala and Hippocampus in Pathologically Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration.
Arch Neurol,
October 1, 2006;
63(10):
1434 - 1439.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Levy and B. Dubois
Apathy and the Functional Anatomy of the Prefrontal Cortex-Basal Ganglia Circuits
Cereb Cortex,
July 1, 2006;
16(7):
916 - 928.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Boxer, S. Garbutt, K. P. Rankin, J. Hellmuth, J. Neuhaus, B. L. Miller, and S. G. Lisberger
Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degeneration.
J. Neurosci.,
June 7, 2006;
26(23):
6354 - 6363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ash, P. Moore, S. Antani, G. McCawley, M. Work, and M. Grossman
Trying to tell a tale: Discourse impairments in progressive aphasia and frontotemporal dementia
Neurology,
May 9, 2006;
66(9):
1405 - 1413.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M F Mendez, A McMurtray, A K Chen, J S Shapira, F Mishkin, and B L Miller
Functional neuroimaging and presenting psychiatric features in frontotemporal dementia
J. Neurol. Neurosurg. Psychiatry,
January 1, 2006;
77(1):
4 - 7.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Rosen, S. C. Allison, G. F. Schauer, M. L. Gorno-Tempini, M. W. Weiner, and B. L. Miller
Neuroanatomical correlates of behavioural disorders in dementia
Brain,
November 1, 2005;
128(11):
2612 - 2625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Whitwell, K. A. Josephs, M. N. Rossor, J. M. Stevens, T. Revesz, J. L. Holton, S. Al-Sarraj, A. K. Godbolt, N. C. Fox, and J. D. Warren
Magnetic Resonance Imaging Signatures of Tissue Pathology in Frontotemporal Dementia
Arch Neurol,
September 1, 2005;
62(9):
1402 - 1408.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Chang, C. Lomen-Hoerth, J. Murphy, R. G. Henry, J. H. Kramer, B. L. Miller, and M. L. Gorno-Tempini
A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD
Neurology,
July 12, 2005;
65(1):
75 - 80.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S D Gale, L Baxter, N Roundy, and S C Johnson
Traumatic brain injury and grey matter concentration: a preliminary voxel based morphometry study
J. Neurol. Neurosurg. Psychiatry,
July 1, 2005;
76(7):
984 - 988.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Cordato, A. J. Duggins, G. M. Halliday, J. G. L. Morris, and C. Pantelis
Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy
Brain,
June 1, 2005;
128(6):
1259 - 1266.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K P Rankin, E Baldwin, C Pace-Savitsky, J H Kramer, and B L Miller
Self awareness and personality change in dementia
J. Neurol. Neurosurg. Psychiatry,
May 1, 2005;
76(5):
632 - 639.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. W. Seeley, A. M. Bauer, B. L. Miller, M. L. Gorno-Tempini, J. H. Kramer, M. Weiner, and H. J. Rosen
The natural history of temporal variant frontotemporal dementia
Neurology,
April 26, 2005;
64(8):
1384 - 1390.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. F. Boeve, I. W. Tremont-Lukats, A. J. Waclawik, J. R. Murrell, B. Hermann, C. R. Jack Jr, M. M. Shiung, G. E. Smith, A. R. Nair, N. Lindor, et al.
Longitudinal characterization of two siblings with frontotemporal dementia and parkinsonism linked to chromosome 17 associated with the S305N tau mutation
Brain,
April 1, 2005;
128(4):
752 - 772.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Diehl, A. U. Monsch, C. Aebi, S. Wagenpfeil, S. Krapp, T. Grimmer, W. Seeley, H. Forstl, and A. Kurz
Frontotemporal Dementia, Semantic Dementia, and Alzheimer's Disease: The Contribution of Standard Neuropsychological Tests to Differential Diagnosis
J Geriatr Psychiatry Neurol,
March 1, 2005;
18(1):
39 - 44.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Graham, R. Davies, J. Xuereb, G. Halliday, J. Kril, H. Creasey, K. Graham, and J. Hodges
Pathologically proven frontotemporal dementia presenting with severe amnesia
Brain,
March 1, 2005;
128(3):
597 - 605.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Jeong, S. S. Cho, J. M. Park, S. J. Kang, J. S. Lee, E. Kang, D. L. Na, and S. E. Kim
18F-FDG PET Findings in Frontotemporal Dementia: An SPM Analysis of 29 Patients
J. Nucl. Med.,
February 1, 2005;
46(2):
233 - 239.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Burton, I. G. McKeith, D. J. Burn, E. D. Williams, and J. T. O'Brien
Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls
Brain,
April 1, 2004;
127(4):
791 - 800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Liu, B. L. Miller, J. H. Kramer, K. Rankin, C. Wyss-Coray, R. Gearhart, L. Phengrasamy, M. Weiner, and H. J. Rosen
Behavioral disorders in the frontal and temporal variants of frontotemporal dementia
Neurology,
March 9, 2004;
62(5):
742 - 748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Grossman, C. McMillan, P. Moore, L. Ding, G. Glosser, M. Work, and J. Gee
What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration
Brain,
March 1, 2004;
127(3):
628 - 649.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Boxer, J. H. Kramer, A. -T. Du, N. Schuff, M. W. Weiner, B. L. Miller, and H. J. Rosen
Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment
Neurology,
December 9, 2003;
61(11):
1485 - 1491.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Thompson, K. Patterson, and J. R. Hodges
Left/right asymmetry of atrophy in semantic dementia: Behavioral-cognitive implications
Neurology,
November 11, 2003;
61(9):
1196 - 1203.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Bagary, M. R. Symms, G. J. Barker, S. H. Mutsatsa, E. M. Joyce, and M. A. Ron
Gray and White Matter Brain Abnormalities in First-Episode Schizophrenia Inferred From Magnetization Transfer Imaging
Arch Gen Psychiatry,
August 1, 2003;
60(8):
779 - 788.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Boxer, K. P. Rankin, B. L. Miller, N. Schuff, M. Weiner, M.-L. Gorno-Tempini, and H. J. Rosen
Cinguloparietal Atrophy Distinguishes Alzheimer Disease From Semantic Dementia
Arch Neurol,
July 1, 2003;
60(7):
949 - 956.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A.R.B. Rombouts, J. C. van Swieten, Y. A.L. Pijnenburg, R. Goekoop, F. Barkhof, and P. Scheltens
Loss of frontal fMRI activation in early frontotemporal dementia compared to early AD
Neurology,
June 24, 2003;
60(12):
1904 - 1908.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Broe, J.R. Hodges, E. Schofield, C.E. Shepherd, J.J. Kril, and G.M. Halliday
Staging disease severity in pathologically confirmed cases of frontotemporal dementia
Neurology,
March 25, 2003;
60(6):
1005 - 1011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. P. Rankin, J. H. Kramer, P. Mychack, and B. L. Miller
Double dissociation of social functioning in frontotemporal dementia
Neurology,
January 28, 2003;
60(2):
266 - 271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Rosen, R. J. Perry, J. Murphy, J. H. Kramer, P. Mychack, N. Schuff, M. Weiner, R. W. Levenson, and B. L. Miller
Emotion comprehension in the temporal variant of frontotemporal dementia
Brain,
October 1, 2002;
125(10):
2286 - 2295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. J. Rosen, K. M. Hartikainen, W. Jagust, J. H. Kramer, B. R. Reed, J. L. Cummings, K. Boone, W. Ellis, C. Miller, and B. L. Miller
Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD
Neurology,
June 11, 2002;
58(11):
1608 - 1615.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
