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Neurology 2002;58:1852-1855
© 2002 American Academy of Neurology
Brief Communications

Reduced cortical gray matter in narcolepsy: Preliminary findings with voxel-based morphometry

Christian Kaufmann, MSc, Andreas Schuld, MD, Thomas Pollmächer, MD and Dorothee P. Auer, MD

From the Research Group Neurophysiology of Sleep (Drs. Kaufmann, Schuld, and Pollmächer) and NMR Study Group (Dr. Auer), Max Planck Institute of Psychiatry, Munich, Germany.

Address correspondence and reprint requests to Dr. Thomas Pollmächer, Max Planck Institute of Psychiatry, Kraepelinstr. 10, 80804 Munich, Germany; e-mail: topo{at}mpipsykl.mpg.de

There is a selective loss of hypocretin/orexin-containing hypothalamic neurons in patients with narcolepsy. The authors compared MRI-derived gray matter maps of 12 patients with narcolepsy with matched controls using voxel-based morphometry to ascertain whether there are other structural brain abnormalities. Patients with narcolepsy showed bilateral cortical gray matter reductions predominantly in inferior temporal and inferior frontal brain regions. Relative global gray matter loss was independent of disease duration or medication history. No significant subcortical gray matter alterations were noted.




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