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Neurology 2002;58:1843-1846
© 2002 American Academy of Neurology
Brief Communications

Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening

Robert Forget, PT, PhD, Viorika Tozlovanu, MD, MSc, Andreea Iancu, MD, PhD and Dan Boghen, MD, FRCP(C)

From the Centre de recherche interdisciplinaire en réadaptation du Montréal Métropolitain (Drs. Forget, Tozlovanu, and Iancu), Institut de Réadaptation de Montréal; Department of Neurology (Dr. Boghen), Centre Hospitalier de l’Université de Montréal/Hôtel Dieu; and École de Réadaptation (Dr. Forget) and Centre de Recherche en Sciences Neurologiques (Drs. Forget, Tozlovanu, Iancu, and Boghen), Université de Montréal, Canada.

Address correspondence and reprint requests to Dr. Robert Forget, Centre de recherche interdisciplinaire en réadaptation, Institut de Réadaptation de Montréal, 6300 Darlington, Montréal, Qué H3S 2J4, Canada; e-mail: robert.forget{at}umontreal.ca

Lid movement and EMG of the orbicularis oculi (OOc) were analyzed in 10 patients with apraxia of lid opening associated with blepharospasm before and after botulinum toxin treatment. The latencies to onset and to complete the eye opening and the time during which eye opening was sustained were studied in relation to OOc activity and compared with control values obtained in 12 healthy subjects. Following treatment there was an improvement of all lid opening measurements, a decrease of the abnormally prolonged OOc activity, and a reduction of the functional disability.