Neurology 2002;58:1720-1725
© 2002 American Academy of Neurology
Views & Reviews
Drug therapy in human and experimental transmissible spongiform encephalopathy
Paul Brown, MD
From the Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.
Address correspondence and reprint requests to Dr. Paul Brown, Building 36, Room 4A-19 (MSC-4123), National Institutes of Health, Bethesda, MD 20892-4122; e-mail: brownp{at}ninds.nih.gov
During the past 30 years, over 60 different chemical compounds have been used to treat experimental animals infected with transmissible spongiform encephalopathies (TSE), including a wide variety of anti-infectious agents, immunomodulating drugs, and chemicals interacting with the lympho-reticular system. Some compounds achieved a prolongation of the incubation period, but this effect decreased or disappeared when they were administered at or near the onset of symptomatic disease. Recent in vitro and tissue culture studies support earlier speculation about the importance of a chemical structure containing both water-soluble and lipid-soluble components, evidently as a means of interaction with the misfolded membrane-bound ‘prion’ protein. A number of compounds shown to eliminate the protein (or infectivity) in TSE-infected tissue cultures are the subject of ongoing studies in animals, and are under consideration for human drug trials. As with other recalcitrant infections, combinations of drugs with different modes of action are likely to be necessary for any effective therapy. Also, very recent work in developing antibodies that can neutralize in vitro infection (and, in conjunction with genetic engineering, in vivo infection) has renewed interest in the strategies of both active and passive immunization.
This article has been cited by other articles:
|
|
|
|
 
S. Saddichha and V. Pandey
Alzheimer's and Non-Alzheimer's Dementia: A Critical Review of Pharmacological and Nonpharmacological Strategies
American Journal of Alzheimer's Disease and Other Dementias,
May 1, 2008;
23(2):
150 - 161.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. Larramendy-Gozalo, A. Barret, E. Daudigeos, E. Mathieu, L. Antonangeli, C. Riffet, E. Petit, D. Papy-Garcia, D. Barritault, P. Brown, et al.
Comparison of CR36, a new heparan mimetic, and pentosan polysulfate in the treatment of prion diseases
J. Gen. Virol.,
March 1, 2007;
88(3):
1062 - 1067.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Feraudet, N. Morel, S. Simon, H. Volland, Y. Frobert, C. Creminon, D. Vilette, S. Lehmann, and J. Grassi
Screening of 145 Anti-PrP Monoclonal Antibodies for Their Capacity to Inhibit PrPSc Replication in Infected Cells
J. Biol. Chem.,
March 25, 2005;
280(12):
11247 - 11258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pocchiari, M. Puopolo, E. A. Croes, H. Budka, E. Gelpi, S. Collins, V. Lewis, T. Sutcliffe, A. Guilivi, N. Delasnerie-Laupretre, et al.
Predictors of survival in sporadic Creutzfeldt-Jakob disease and other human transmissible spongiform encephalopathies
Brain,
October 1, 2004;
127(10):
2348 - 2359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Beringue, D. Vilette, G. Mallinson, F. Archer, M. Kaisar, M. Tayebi, G. S. Jackson, A. R. Clarke, H. Laude, J. Collinge, et al.
PrPSc Binding Antibodies Are Potent Inhibitors of Prion Replication in Cell Lines
J. Biol. Chem.,
September 17, 2004;
279(38):
39671 - 39676.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. A. Kocisko, J. D. Morrey, R. E. Race, J. Chen, and B. Caughey
Evaluation of new cell culture inhibitors of protease-resistant prion protein against scrapie infection in mice
J. Gen. Virol.,
August 1, 2004;
85(8):
2479 - 2483.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Solassol, C. Crozet, V. Perrier, J. Leclaire, F. Beranger, A.-M. Caminade, B. Meunier, D. Dormont, J.-P. Majoral, and S. Lehmann
Cationic phosphorus-containing dendrimers reduce prion replication both in cell culture and in mice infected with scrapie
J. Gen. Virol.,
June 1, 2004;
85(6):
1791 - 1799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Doh-ura, K. Ishikawa, I. Murakami-Kubo, K. Sasaki, S. Mohri, R. Race, and T. Iwaki
Treatment of Transmissible Spongiform Encephalopathy by Intraventricular Drug Infusion in Animal Models
J. Virol.,
May 15, 2004;
78(10):
4999 - 5006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
March 9 Highlight and Commentary
Neurology,
March 9, 2004;
62(5):
679 - 679.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Otto, L. Cepek, P. Ratzka, S. Doehlinger, I. Boekhoff, J. Wiltfang, E. Irle, G. Pergande, B. Ellers-Lenz, O. Windl, et al.
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study
Neurology,
March 9, 2004;
62(5):
714 - 718.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Solassol, C. Crozet, and S. Lehmann
Prion propagation in cultured cells
Br. Med. Bull.,
June 1, 2003;
66(1):
87 - 97.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. C. H. May, A. T. Fafarman, S. B. Hong, M. Rogers, L. W. Deady, S. B. Prusiner, and F. E. Cohen
Potent inhibition of scrapie prion replication in cultured cells by bis-acridines
PNAS,
March 18, 2003;
100(6):
3416 - 3421.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
