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Neurology 2002;58:1683-1686
© 2002 American Academy of Neurology
Brief Communications

Bilateral isolated hippocampal malformation in temporal lobe epilepsy

M. Thom, MRCPath, S. M. Sisodiya, PhD, W. R. Lin, PhD, T. Mitchell, MRCP, S. L. Free, PhD, J. Stevens, FRCR and F. Scaravilli, PhD

From the Department of Clinical and Experimental Epilepsy and the Division of Neuropathology, Neurology (Drs. Mitchell, Sisodiya, and Free) and Neuroradiology (Dr. Stevens), Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, United Kingdom.

Address correspondence and reprint requests to Dr. M. Thom, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; e-mail: M.Thom{at}ion.ucl.ac.uk

Hippocampal malformations in patients with epilepsy usually are reported in the context of widespread cortical malformations. Isolated hippocampal malformations are more rarely identified in MRI studies with little documentation of their pathologic appearance. Postmortem examination revealed abnormal position and complex convolutional malformations isolated to the hippocampal formation in an adult with temporal lobe epilepsy in whom MRI demonstrated bilateral hippocampal abnormalities.




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