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Neurology 2002;58:1556-1559
© 2002 American Academy of Neurology
Brief Communications

Long-term response to zonisamide in patients with West syndrome

Y. Suzuki, MD, K. Imai, MD, Y. Toribe, MD, H. Ueda, MD, K. Yanagihara, MD, K. Shimono, MD, T. Okinaga, MD, J. Ono, MD, T. Nagai, MD, T. Matsuoka, MD, T. Tagawa, MD, J. Abe, MD, Y. Morita, MD, Y. Fujikawa, MD, H. Arai, MD, T. Mano, MD and S. Okada, MD

From the Division of Pediatric Neurology (Drs. Suzuki, Toribe, and Ueda), Osaka Medical Center and Research Institute for Maternal and Child Health; Department of Pediatrics (Drs. Imai, Yanagihara, Shimono, and Okinaga), Osaka University Medical School; Department of Special Education (Dr. Ono), Faculty of Education, Wakayama University; Department of Pediatrics (Drs. Nagai and Matsuoka), Toyonaka Municipal Hospital; Department of Pediatrics (Dr. Tagawa), Osaka Koseinenkin Hospital; Department of Pediatrics (Dr. Abe), Hyogo Prefectural Nishinomiya Hospital; Department of Pediatrics (Drs. Morita and Okada), Sakai Municipal Hospital; Department of Pediatrics (Dr. Fujikawa), Mino City Hospital; Department of Pediatric Neurology (Dr. Arai), Bobath Memorial Hospital; Department of Pediatrics (Dr. Mano), Osaka Prefectural General Hospital; and The Research Foundation for Microbial Diseases of Osaka University (Dr. Okada), Japan.

Address correspondence and reprint requests to Dr. Y. Suzuki at Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, 840, Murodo-cho, Izumi, Osaka 594-1101, Japan; e-mail: yasuzuki{at}mch.pref.osaka.jp

The long-term effectiveness of zonisamide (ZNS) was evaluated in 11 patients with West syndrome (7 symptomatic) who had cessation of spasms with ZNS monotherapy. During the follow-up period (24 to 79 months, mean = 53 months), this response was maintained in 7 patients (3 symptomatic, relapse rate = 36%), including 2 children in whom ZNS was successfully discontinued. No serious adverse reactions were noted. ZNS may be both effective and well tolerated for the treatment of West syndrome.




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