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Neurology 2002;58:1546-1550
© 2002 American Academy of Neurology
Brief Communications

Long-term follow up of subthalamic nucleus stimulation in Parkinson’s disease

L. M.A. Romito, MD, M. Scerrati, MD, M. F. Contarino, MD, A. R. Bentivoglio, MD PhD, P. Tonali, MD and A. Albanese, MD

From the Istituto di Neurologia (Drs. Romito, Contarino, Bentivoglio, Tonali, and Albanese), and Istituto di Neurochirurgia (Dr. Scerrati), Università Cattolica del Sacro Cuore, Rome; and Istituto Neurologico Nazionale "Carlo Besta" (Dr. Albanese), Milan, Italy.

Address correspondence and reprint requests to Prof. Alberto Albanese, Istituto Nazionale Neurologico Carlo Besta, Via G. Celoria, 11, 20133 Milano, Italy; e-mail alberto.albanese{at}rm.unicatt.it

Twenty-two patients with PD received bilateral implants for high frequency stimulation of the subthalamic nucleus. The patients were treated for more than 1 year (up to 36 months). At the last visit, the Unified Parkinson Disease Rating Scale (UPDRS) motor score without medication improved by 50.2% (p < 0.001) and the UPDRS activities of daily living score improved by 68.4% (p < 0.001). The most common long-lasting adverse events were hypophonia and dysarthria; transient events were increased sexuality and mania. The surgical procedure induced transient intraoperative psychosis in seven patients.




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