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Neurology 2001;57:1488-1491
© 2001 American Academy of Neurology
Brief Communications

Fish oil supplementation improves visual evoked potentials in children with phenylketonuria

S. Beblo, MD, H. Reinhardt, BS, A. C. Muntau, MD, W. Mueller–Felber, MD, A. A. Roscher, MD and B. Koletzko, MD

From the Division of Metabolic Diseases and Nutrition (Drs. Beblo, Muntau, Roscher, and Koletzko, and H. Reinhardt), Dr. von Haunersches Kinderspital; and Friedrich-Baur-Institut (Dr. Mueller-Felber), Ludwig-Maximilians-Universität München, Germany.

Address correspondence and reprint requests to Dr. B. Koletzko, Division of Metabolic Disorders and Nutrition, University of Munich, Lindwurmstr. 4, D-80337 Munich, Germany; e-mail: Berthold.Koletzko{at}kk-i.med.uni-muenchen.de

Visual evoked potentials (VEP) were measured in 36 patients with early-treated phenylketonuria (PKU; aged 1 to 11 years) and good metabolic control before and after supplementation with omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) from fish oil. Patients with PKU had significantly longer P100 latencies than 22 age-matched control subjects. After 3 months of LC-PUFA supplementation, VEP latencies improved significantly in PKU patients but did not change in 12 untreated healthy children. The authors conclude that omega-3 LC-PUFA are essential substrates for nervous system function even beyond infancy.




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C Agostoni, E Verduci, N Massetto, L Fiori, G Radaelli, E Riva, and M Giovannini
Long term effects of long chain polyunsaturated fats in hyperphenylalaninemic children
Arch. Dis. Child., July 1, 2003; 88(7): 582 - 583.
[Abstract] [Full Text] [PDF]


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