| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Neurosurgery and Neurology, University of Utah, Salt Lake City.
Address correspondence and reprint requests to Dr. Wendy J. Lombardi, Department of Neurosurgery, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132; e-mail: wendy.lombardi{at}hsc.utah.edu
Objective: — To assess cognitive and affective functioning in patients with essential tremor (ET).
Background: — ET is traditionally thought to occur in isolation, without other neurologic abnormalities or cognitive changes. Recent evidence of gait disturbance and bradykinesia in these patients suggests that the neurologic abnormalities in ET may be more widespread than was once thought. Cognitive function in these patients has not been the subject of in-depth study.
Methods: — Cognitive performance and mood were assessed in 18 consecutive patients with ET and 18 consecutive patients with PD who visited the neurosurgical clinic for surgical treatment of their symptoms.
Results: — The patients with ET were found to have deficits on tests of verbal fluency, naming, mental set-shifting, verbal memory, and working memory, as well as higher levels of depression. In contrast to these areas of deficit, their performance was better than that of the normative sample on several tests of verbal and nonverbal conceptualization and reasoning. Tremor severity was not correlated with cognitive deficits. Patients with PD had deficits on the same tests that were impaired in the ET group and on tests of visuospatial processes. Direct comparison of the ET and PD groups showed greater impairment in facial perception in the PD group and greater impairment in verbal fluency and working memory in the ET group.
Conclusion: — Patients with ET have deficits in specific aspects of neuropsychological functioning, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests involvement of frontocerebellar circuits in this disease.
This article has been cited by other articles:
|
|
 |
|
  N. Hattori, M. Swan, G. A. Stobbe, J. M. Uomoto, S. Minoshima, D. Djang, R. Krishnananthan, and D. H. Lewis Differential SPECT Activation Patterns Associated with PASAT Performance May Indicate Frontocerebellar Functional Dissociation in Chronic Mild Traumatic Brain Injury J. Nucl. Med., July 1, 2009; 50(7): 1054 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.H. Shin, B.S. Han, H.S. Kim, and P.H. Lee Diffusion Tensor Imaging in Patients With Essential Tremor AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 151 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Louis, P. L. Faust, J.-P. G. Vonsattel, L. S. Honig, A. Rajput, C. A. Robinson, A. Rajput, R. Pahwa, K. E. Lyons, G.W. Ross, et al. Neuropathological changes in essential tremor: 33 cases compared with 21 controls Brain, December 1, 2007; 130(12): 3297 - 3307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Louis, J. Benito-Leon, R. Ottman, F. Bermejo-Pareja, and On behalf of the Neurological Disorders in Central A population-based study of mortality in essential tremor Neurology, November 20, 2007; 69(21): 1982 - 1989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Deng, W. Le, and J. Jankovic Genetics of essential tremor Brain, June 1, 2007; 130(6): 1456 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kronenbuerger, M. Gerwig, B. Brol, F. Block, and D. Timmann Eyeblink conditioning is impaired in subjects with essential tremor Brain, June 1, 2007; 130(6): 1538 - 1551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Sahin, M. Terzi, S. Ucak, O. Yapici, T. Basoglu, and M. Onar Frontal functions in young patients with essential tremor: a case comparison study. J Neuropsychiatry Clin Neurosci, December 1, 2006; 18(1): 64 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Benito-Leon, E. D. Louis, F. Bermejo-Pareja, and on behalf of the Neurological Disorders in Central Elderly-onset essential tremor is associated with dementia Neurology, May 23, 2006; 66(10): 1500 - 1505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Benito-Leon, E. D. Louis, F. Bermejo-Pareja, and on behalf of the Neurological Disorders in Central Population-based case-control study of cognitive function in essential tremor Neurology, January 10, 2006; 66(1): 69 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L J Findley Expanding clinical dimensions of essential tremor J. Neurol. Neurosurg. Psychiatry, July 1, 2004; 75(7): 948 - 949. [Full Text] [PDF]
|
|
|
|
|
|
A Chatterjee, E C Jurewicz, L M Applegate, and E D Louis Personality in essential tremor: further evidence of non-motor manifestations of the disease J. Neurol. Neurosurg. Psychiatry, July 1, 2004; 75(7): 958 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J A Fields, A I Troster, S P Woods, C I Higginson, S B Wilkinson, K E Lyons, W C Koller, and R Pahwa Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor J. Neurol. Neurosurg. Psychiatry, March 1, 2003; 74(3): 305 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Cohen, S. Pullman, E. Jurewicz, D. Watner, and E. D. Louis Rest Tremor in Patients With Essential Tremor: Prevalence, Clinical Correlates, and Electrophysiologic Characteristics Arch Neurol, March 1, 2003; 60(3): 405 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Leehey, R. P. Munhoz, A. E. Lang, J. A. Brunberg, J. Grigsby, C. Greco, S. Jacquemont, F. Tassone, A. M. Lozano, P. J. Hagerman, et al. The Fragile X Premutation Presenting as Essential Tremor Arch Neurol, January 1, 2003; 60(1): 117 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Louis, K. Marder, E. C. Jurewicz, D. Watner, G. Levy, and H. Mejia-Santana Body Mass Index in Essential Tremor Arch Neurol, August 1, 2002; 59(8): 1273 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Duane, K. J. Vermilion, W.J. Lombardi, D.J. Woolston, J.W. Roberts, and R.E. Gross Cognitive deficits in patients with essential tremor Neurology, June 11, 2002; 58(11): 1706 - 1707. [Full Text] [PDF]
|
|
|
|
 |
|
 Cognitive Impairments in Essential Tremor and Multiple Sclerosis Journal Watch Psychiatry, November 15, 2001; 2001(1115): 5 - 5. [Full Text]
|
|
Read all Correspondence
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
