Neurology 2001;57:1885-1888
© 2001 American Academy of Neurology
Brief Communications
Onset of multiple sclerosis associated with anti-TNF therapy
Nancy L. Sicotte, MD and
Rhonda R. Voskuhl, MD
From the Division of Brain Mapping (Dr. Sicotte), Department of Neurology (Drs. Sicotte and Voskuhl), UCLA School of Medicine, Los Angeles, CA.
Address correspondence and reprint requests to Dr. Nancy L. Sicotte, 710 Westwood Boulevard, Rm. A135, Los Angeles, CA 90095; e-mail: nsicotte{at}ucla.edu
Therapies aimed at inhibiting tumor necrosis factor (TNF), a proinflammatory cytokine implicated in autoimmune disease are effective, especially for rheumatoid arthritis. We report a patient with new onset MS closely associated with the initiation of anti-TNF therapy for juvenile rheumatoid arthritis. It is possible that the inhibition of TNF triggered MS in this individual.
This article has been cited by other articles:
|
|
|
|
 
N. JACOB and C. O. JACOB
On Anti-Tumor Necrosis Factor-induced Systemic Lupus Erythematosus
J Rheumatol,
January 1, 2010;
37(1):
3 - 5.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Giansanti, M. Ramazzotti, M. Giuntoli, G. Virgili, L. Vannozzi, D. Degl'Innocenti, and U. Menchini
Intravitreal Infliximab Clearance in a Rabbit Model: Different Sampling Methods and Assay Techniques
Invest. Ophthalmol. Vis. Sci.,
November 1, 2009;
50(11):
5328 - 5335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Mukai, T. Nakamura, Y. Yoshioka, H. Shibata, Y. Abe, T. Nomura, M. Taniai, T. Ohta, S. Nakagawa, S.-i. Tsunoda, et al.
Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists
J. Biochem.,
August 1, 2009;
146(2):
167 - 172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Helliwell and A. J. Coles
Monoclonal antibodies in multiple sclerosis treatment: current and future steps
Therapeutic Advances in Neurological Disorders,
July 1, 2009;
2(4):
195 - 203.
[PDF]
|
|
|
|
|
|
|
E. C. Somers, S. L. Thomas, L. Smeeth, and A. J. Hall
Are Individuals With an Autoimmune Disease at Higher Risk of a Second Autoimmune Disorder?
Am. J. Epidemiol.,
March 15, 2009;
169(6):
749 - 755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Jacob, H. Yang, L. Pricop, Y. Liu, X. Gao, S. G. Zheng, J. Wang, H.-X. Gao, C. Putterman, M. N. Koss, et al.
Accelerated Pathological and Clinical Nephritis in Systemic Lupus Erythematosus-Prone New Zealand Mixed 2328 Mice Doubly Deficient in TNF Receptor 1 and TNF Receptor 2 via a Th17-Associated Pathway
J. Immunol.,
February 15, 2009;
182(4):
2532 - 2541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Moravan and B. M. Segal
Treatment of CNS sarcoidosis with infliximab and mycophenolate mofetil
Neurology,
January 27, 2009;
72(4):
337 - 340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kumpfel, L-A Hoffmann, H. Pellkofer, W. Pollmann, W. Feneberg, R. Hohlfeld, and P. Lohse
Multiple sclerosis and the TNFRSF1A R92Q mutation: Clinical characteristics of 21 cases
Neurology,
November 25, 2008;
71(22):
1812 - 1820.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C Prendiville, M O'Doherty, P Moriarty, and L Cassidy
The use of infliximab in ocular inflammation
Br J Ophthalmol,
June 1, 2008;
92(6):
823 - 825.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Giansanti, M. Ramazzotti, L. Vannozzi, E. Rapizzi, T. Fiore, B. Iaccheri, D. Degl' Innocenti, D. Moncini, and U. Menchini
A Pilot Study on Ocular Safety of Intravitreal Infliximab in a Rabbit Model
Invest. Ophthalmol. Vis. Sci.,
March 1, 2008;
49(3):
1151 - 1156.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Shibata, Y. Yoshioka, A. Ohkawa, K. Minowa, Y. Mukai, Y. Abe, M. Taniai, T. Nomura, H. Kayamuro, H. Nabeshi, et al.
Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-{alpha} Antagonist
J. Biol. Chem.,
January 11, 2008;
283(2):
998 - 1007.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Plant, H. A. Iocca, Y. Wang, J. C. Thrash, B. P. O'Connor, H. A. Arnett, Y.-X. Fu, M. J. Carson, and J. P.-Y. Ting
Lymphotoxin {beta} Receptor (Lt{beta}R): Dual Roles in Demyelination and Remyelination and Successful Therapeutic Intervention Using Lt{beta}R-Ig Protein
J. Neurosci.,
July 11, 2007;
27(28):
7429 - 7437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Choudry and J. W. Chan
An Update on Monoclonal Antibody Therapies in Multiple Sclerosis
Journal of Pharmacy Practice,
April 1, 2007;
20(2):
167 - 180.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. Dale, M. Davis, and D. L. Faustman
A role for transcription factor NF-{kappa}B in autoimmunity: possible interactions of genes, sex, and the immune response
Advan Physiol Educ,
December 1, 2006;
30(4):
152 - 158.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Plumb, S McQuaid, A K Cross, J Surr, G Haddock, R A. Bunning, and M N Woodroofe
Upregulation of ADAM-17 expression in active lesions in multiple sclerosis
Multiple Sclerosis,
August 1, 2006;
12(4):
375 - 385.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. S. Titelbaum, A. Degenhardt, and R. P. Kinkel
Anti-Tumor Necrosis Factor Alpha-Associated Multiple Sclerosis
AJNR Am. J. Neuroradiol.,
June 1, 2005;
26(6):
1548 - 1550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E W Lindstedt, G S Baarsma, R W A M Kuijpers, and P M van Hagen
Anti-TNF-{alpha} therapy for sight threatening uveitis
Br J Ophthalmol,
May 1, 2005;
89(5):
533 - 536.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-M. Huang, X. Liu, K. Steffensen, A. Sanna, G. Arru, M. L. Fois, G. Rosati, S. Sotgiu, and H. Link
Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden
Multiple Sclerosis,
February 1, 2005;
11(1):
16 - 23.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Ledingham, C. Deighton, and on behalf of the British Society for Rheumatology
Update on the British Society for Rheumatology guidelines for prescribing TNF{alpha} blockers in adults with rheumatoid arthritis (update of previous guidelines of April 2001)
Rheumatology,
February 1, 2005;
44(2):
157 - 163.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Rodriguez-Escalera, J. Belzunegui, L. Lopez-Dominguez, C. Gonzalez, and M. Figueroa
Multifocal motor neuropathy with conduction block in a patient with rheumatoid arthritis on infliximab therapy
Rheumatology,
January 1, 2005;
44(1):
132 - 133.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G Horneff, H Schmeling, T Biedermann, I Foeldvari, G Ganser, H J Girschick, T Hospach, H I Huppertz, R Keitzer, R M Kuster, et al.
The German etanercept registry for treatment of juvenile idiopathic arthritis
Ann Rheum Dis,
December 1, 2004;
63(12):
1638 - 1644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K L Hyrich, A J Silman, K D Watson, and D P M Symmons
Anti-tumour necrosis factor {alpha} therapy in rheumatoid arthritis: an update on safety
Ann Rheum Dis,
December 1, 2004;
63(12):
1538 - 1543.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L J Clifford and J D Rossiter
Peripheral visual field loss following treatment with etanercept
Br J Ophthalmol,
June 1, 2004;
88(6):
842 - 842.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. A. Arnett, Y. Wang, G. K. Matsushima, K. Suzuki, and J. P.-Y. Ting
Functional Genomic Analysis of Remyelination Reveals Importance of Inflammation in Oligodendrocyte Regeneration
J. Neurosci.,
October 29, 2003;
23(30):
9824 - 9832.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P.B. Lappin and L.E. Black
Immune Modulator Studies in Primates: The Utility of Flow Cytometry and Immunohistochemistry in the Identification and Characterization of Immunotoxicity
Toxicol Pathol,
January 1, 2003;
31(1_suppl):
111 - 118.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. A. Murphy, R. M. Hoek, M. T. Wiekowski, S. A. Lira, and J. D. Sedgwick
Interactions Between Hemopoietically Derived TNF and Central Nervous System-Resident Glial Chemokines Underlie Initiation of Autoimmune Inflammation in the Brain
J. Immunol.,
December 15, 2002;
169(12):
7054 - 7062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
