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Neurology 2001;56:1216-1218
© 2001 American Academy of Neurology
Brief Communications

Proliferation index is related to patient age in glioblastoma

P.E. McKeever, MD, PhD;, L. Junck, MD;, M.S. Strawderman, MS;, M. Blaivas, MD, PhD;, A. Tkaczyk, MS;, M.A. Cates, BA;, M. Yan, BS; and L. Li, MS

From the Departments of Pathology (Drs. McKeever and Blaivas and A. Tkaczyk, M.A. Cates, and M. Yan) and Neurology (Dr. Junck), the Cancer Registry, and the Comprehensive Cancer Center (M.S. Strawderman and L. Li), University of Michigan, Ann Arbor.

Address correspondence and reprint requests to Dr. Paul E. McKeever, Department of Pathology, Box 0602, University of Michigan Medical School, 1301 Catherine Rd., Ann Arbor, MI 48109; e-mail: paulmcke{at}umich.edu

Younger patients with glioblastomas have a significantly better prognosis than do older patients. To determine whether patient age might be related to proliferation of glioblastoma cells, glioblastomas from patients of different ages were stained with the Molecular Immunology Borstel number 1 antibody to detect proliferating cells. Younger patient age was a significant predictor of a low Molecular Immunology Borstel number 1 proliferation index (p = 0.0001). This previously unreported association favors an intrinsic difference in the type of glioblastomas that afflict younger patients.




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[Abstract] [Full Text] [PDF]