| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Neurology (Drs. Rättyä, Turkka, Myllylä, and Isojärvi), Clinical Chemistry (Dr. Pakarinen), and Urology (Dr. Lukkarinen), University of Oulu; Medical School (Dr. Knip), University of Tampere; and Department of Neurology (Dr. Kotila), University of Helsinki, Finland.
Address correspondence and reprint requests to Dr. Johanna Rättyä, Department of Neurology, University of Oulu, Finland, Kajaanintie 50, FIN-90220 Oulu; e-mail: johanna.rattya{at}oulu.fi
BACKGROUND: Recent observations have indicated that reproductive endocrine disorders are common among women taking valproate (VPA) for epilepsy, but it is not known whether respective abnormalities develop in men taking VPA for epilepsy. Carbamazepine (CBZ) may induce endocrine disorders in men with epilepsy, but the endocrine effects of oxcarbazepine (OXC) are not known.
METHODS: Reproductive endocrine function was evaluated in 90 men taking VPA (n = 21), CBZ (n = 40), or OXC (n = 29) as monotherapy for epilepsy and in 25 healthy control men.
RESULTS: Twelve men (57%) taking VPA had increased serum androgen levels. The mean serum level of androstenedione was high in patients taking VPA. Serum levels of dehydroepiandrosterone sulfate were low, and serum concentrations of sex hormone–binding globulin (SHBG) were high in men taking CBZ. The endocrine effects of OXC seemed to be dose-dependent, because serum hormone levels were normal in patients with low OXC doses (<900 mg/day), but serum concentrations of testosterone, gonadotropins, and SHBG were high in patients with a daily OXC dose 
900 mg.
CONCLUSIONS: VPA increases serum androgen concentrations in men with epilepsy. The endocrine effects of CBZ and OXC were different, because CBZ appears to decrease the bioactivity of androgens, whereas OXC does not.
This article has been cited by other articles:
|
|
 |
|
  J. A. Talbot, R. Sheldrick, H. Caswell, and S. Duncan Sexual function in men with epilepsy: How important is testosterone? Neurology, April 15, 2008; 70(16): 1346 - 1352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Artama, J.I.T. Isojarvi, and A. Auvinen Antiepileptic drug use and birth rate in patients with epilepsy--a population-based cohort study in Finland Hum. Reprod., September 1, 2006; 21(9): 2290 - 2295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Devinsky Neurologist-induced sexual dysfunction: Enzyme-inducing antiepileptic drugs Neurology, October 11, 2005; 65(7): 980 - 981. [Full Text] [PDF]
|
|
|
|
|
|
A. G. Herzog, F. W. Drislane, D. L. Schomer, P. B. Pennell, E. B. Bromfield, B. A. Dworetzky, E. L. Farina, and C. A. Frye Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy Neurology, October 11, 2005; 65(7): 1016 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Anderson Pharmacogenetics and enzyme induction/inhibition properties of antiepileptic drugs Neurology, November 23, 2004; 63(10_suppl_4): S3 - S8. [Abstract] [Full Text]
|
|
|
|
|
|
P. W. Kaplan Reproductive health effects and teratogenicity of antiepileptic drugs Neurology, November 23, 2004; 63(10_suppl_4): S13 - S23. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Artama, J. I. T. Isojarvi, J. Raitanen, and A. Auvinen Birth Rate among Patients with Epilepsy: A Nationwide Population-based Cohort Study in Finland Am. J. Epidemiol., June 1, 2004; 159(11): 1057 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Gates Epilepsy versus antiepileptic drugs and gonadal function in men Neurology, January 27, 2004; 62(2): 174 - 175. [Full Text] [PDF]
|
|
|
|
|
|
J. Bauer, S. Blumenthal, M. Reuber, and B. Stoffel-Wagner Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy Neurology, January 27, 2004; 62(2): 243 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I.T. Isojarvi, E. Lofgren, K. S.T. Juntunen, A. J. Pakarinen, M. Paivansalo, I. Rautakorpi, and L. Tuomivaara Effect of epilepsy and antiepileptic drugs on male reproductive health Neurology, January 27, 2004; 62(2): 247 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. T. Isojarvi Reproductive dysfunction in women with epilepsy Neurology, September 1, 2003; 61(90062): S27 - 34. [Abstract] [Full Text]
|
|
|
|
|
|
V. Pylvanen, M. Knip, A. J. Pakarinen, J. Turkka, M. Kotila, J. Rattya, V. V. Myllyla, and J. I.T. Isojarvi Fasting serum insulin and lipid levels in men with epilepsy Neurology, February 25, 2003; 60(4): 571 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Bauer, J I T Isojarvi, A G Herzog, M Reuber, D Polson, E Tauboll, P Genton, H van der Ven, B Roesing, G J Luef, et al. Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management J. Neurol. Neurosurg. Psychiatry, August 1, 2002; 73(2): 121 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Endocrine Effects of Antiepileptic Drugs in Men Journal Watch Psychiatry, February 6, 2001; 2001(206): 5 - 5. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
