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Neurology 2000;54:1864-1866
© 2000 American Academy of Neurology


Brief Communications

Pure topographic disorientation: A distinctive syndrome with varied localization

T. Alsaadi, MD, J. R. Binder, MD, R. M. Lazar, PhD, T. Doorani, MD and J. P. Mohr, MD

From the Department of Neurology (Drs. Alsaadi, Binder, and Doorani), Medical College of Wisconsin, Milwaukee; and the Neurological Institute (Drs. Lazar and Mohr), Columbia-Presbyterian Medical Center, New York, NY.

Address correspondence and reprint requests to Dr. Taoufik Alsaadi, Department of Neurology, Medical College of Wisconsin, 9200 Wisconsin Avenue, Milwaukee, WI 53226.

Pure topographic disorientation (TD), defined as impaired recall of routes in familiar surroundings, has been attributed to lesions of the right parahippocampus. The authors present three patients encountered consecutively with TD and compare them to previously published cases. Lesions causing TD included a right splenial/cuneus infarct, a right > left medial temporo-occipital infarct, and a left splenial infarct. TD as an isolated symptom may occur from lesion in a variety of posterior medial locations, including the parahippocampus, splenium, and retrosplenial cortex.

Key words: Topographic disorientation—Corpus callosum—Hippocampus







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