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From the Departments of Neurology (Drs. Lopez, Becker, Kaufer, and DeKosky), Psychiatry (Dr. Lopez, Becker, Kaufer, and DeKosky), Pathology (Division of Neuropathology) (Dr. Hamilton), and Epidemiology (Dr. Wisniewski), Alzheimer’s Disease Research Center, University of Pittsburgh School of Medicine, PA.
Address correspondence and reprint requests to Dr. Oscar L. Lopez, Neuropsychology Research Program, 3600 Forbes Avenue, Suite 502, Pittsburgh, PA 15213.
OBJECTIVE: To examine the differences in the pattern of progression between AD and AD with Lewy bodies (AD+LB).
METHODS: The authors examined predictors of functional and cognitive disability, institutionalization, and death, as well as time to the development of psychosis (e.g., delusions, hallucinations), extrapyramidal signs (EPS), diurnal hypersomnia, and depression in 185 patients with definite AD and 60 with autopsy-confirmed AD+LB. In addition, they analyzed a selected group of patients who did not have comorbid systemic or CNS disease that may have affected progression of the disease (AD = 98 versus AD+LB = 44). The mean follow-up was 58.91 ± 35.2 months.
RESULTS: All cases: Patients with AD+LB had faster time to the development of EPS and diurnal hypersomnia, but not to the development of psychosis or depression. The rate of cognitive and functional decline, time to institutionalization, and physical survival was not different between AD+LB and AD. Selected cases: Patients with AD+LB developed earlier EPS and diurnal hypersomnia than AD patients, and there was a trend to develop earlier major depression, but no differences were noted in time to psychosis. Patients with AD+LB had a faster time to institutionalization than those with AD. The rate of cognitive and functional decline and physical survival was not different between AD+LB and AD in these selected cases.
CONCLUSION: Patients with AD+LB can develop EPS and diurnal hypersomnia earlier and have faster time to institutionalization than those with AD alone, but cognitive and functional decline and physical survival are similar between these two entities.
Key words: Predictors of progression—AD—Lewy bodies
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